909302-84-7

Basic information

• Product Name: 1-Bromo-2-ethoxy-3-fluoro-benzene
• Synonyms: 1-Bromo-2-ethoxy-3-fluoro-benzene
• CAS NO: 909302-84-7
• Molecular Formula: C₈H₈BrFO
• Molecular Weight: 219.05
• Mol File: 909302-84-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Bromo-2-ethoxy-3-fluoro-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-ethoxy-3-fluoro-benzene(909302-84-7)
• EPA Substance Registry System: 1-Bromo-2-ethoxy-3-fluoro-benzene(909302-84-7)

Safety Data

• Hazardous Substances Data: 909302-84-7(Hazardous Substances Data)

Usage

Explanation

The compound's name is derived from its structure, which includes a bromine atom at the 1st position, an ethoxy group at the 2nd position, and a fluorine atom at the 3rd position on a benzene ring.

Explanation

The molecular formula represents the number of carbon (C), hydrogen (H), bromine (Br), fluorine (F), and oxygen (O) atoms in the compound, which are 8, 8, 1, 1, and 1, respectively.

Explanation

The compound is a liquid at room temperature and is colorless, meaning it does not have any visible color.

Explanation

The boiling point is the temperature at which the compound transitions from a liquid to a gas, which is between 210 and 212 degrees Celsius for 1-bromo-2-ethoxy-3-fluoro-benzene.

Explanation

The density of the compound is 1.489 grams per cubic centimeter, which is a measure of its mass per unit volume.

Explanation

1-Bromo-2-ethoxy-3-fluoro-benzene is used as a building block or intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, dyes, polymers, and other specialty chemicals.

Explanation

The compound is known for its potential toxicity, which means it can cause harm to living organisms if not handled properly. It should be used and stored in a controlled laboratory setting with appropriate safety measures.

Explanation

Due to its potential toxicity, it is essential to handle 1-bromo-2-ethoxy-3-fluoro-benzene with care and follow safety protocols when working with it in a laboratory environment.

Physical State

Colorless liquid

Boiling Point

210-212°C

Density

1.489 g/cm^3

Applications

Organic synthesis, pharmaceuticals, agrochemicals, dyes, polymers, and specialty chemicals

Toxicity

Potentially toxic

Safety Precautions

Handle with care in a controlled laboratory setting

Upstream product

• 2040-89-3 2-bromo-6-fluorophenol 
• 75-03-6 ethyl iodide 
• 74-96-4 ethyl bromide 

Downstream Products

• 909302-86-9 C₁₂H₁₇FO₂ 
• 909302-85-8 2-ethoxy-3-fluorophenol 

Relevant articles and documents

Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression

We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity for the GABAA receptor, together with a unique affinity for the NMDA receptor, different to propanidid and AZD3043. In animal models, compound 55 showed stronger hypnotic potency and longer duration of LORR than propanidid and AZD3043, but also maintained a rapid recovery time to walking and behavioral recovery. In particular, compound 55 displayed reflex depression during infusion.

PROCESS FOR PRODUCING 1,2-DIALKOXY-3-FLUOROBENZENE

The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

Process for producing 1,2-dialkoxy-3-fluorobenzene

The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.