90945-94-1

Basic information

• Product Name: 2-METHYL-QUINOLINE-4-THIOL
• Synonyms: 2-METHYL-QUINOLINE-4-THIOL;4-MERCAPTO-2-METHYLQUINOLINE
• CAS NO: 90945-94-1
• Molecular Formula: C10H9NS
• Molecular Weight: 175.25
• Mol File: 90945-94-1.mol

Chemical Properties

• Boiling Point: 274.2°Cat760mmHg
• Flash Point: 119.7°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.00547mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: 2-METHYL-QUINOLINE-4-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-QUINOLINE-4-THIOL(90945-94-1)
• EPA Substance Registry System: 2-METHYL-QUINOLINE-4-THIOL(90945-94-1)

Safety Data

• Hazardous Substances Data: 90945-94-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-QUINOLINE-4-THIOL is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
2-METHYL-QUINOLINE-4-THIOL is used as a building block for the synthesis of agrochemicals, aiding in the creation of pesticides and other agricultural chemicals to protect crops and enhance yields.
Used in Dye Industry:
2-METHYL-QUINOLINE-4-THIOL is used as a building block for the synthesis of dyes, playing a role in the production of colorants for various applications, including textiles, plastics, and printing inks.
Used as a Corrosion Inhibitor:
2-METHYL-QUINOLINE-4-THIOL is used as a corrosion inhibitor to protect metal surfaces from degradation and extend the lifespan of materials used in various industries.
Used as a Photoinitiator:
2-METHYL-QUINOLINE-4-THIOL is used as a photoinitiator in the field of polymer chemistry, initiating the curing process of light-sensitive materials and contributing to the production of advanced materials with specific properties.
Used as an Antioxidant:
2-METHYL-QUINOLINE-4-THIOL is used as an antioxidant to prevent the oxidation of substances, which can be beneficial in various applications, including the stabilization of chemicals and the preservation of materials.

InChI:InChI=1/C10H9NS/c1-7-6-10(12)8-4-2-3-5-9(8)11-7/h2-6H,1H3,(H,11,12)

Upstream product

• 5660-24-2 2-methyl-1H-quinolin-4-one 
• 607-67-0 4-hydroxy-2-methylquinoline 

Downstream Products

• 1089196-59-7 C₂₁H₂₀BrN₃O₃S 
• 1029014-43-4 (E)-N'-(3,4-dimethoxybenzylidene)-2-(2-methylquinolin-4-ylthio)acetohydrazide 
• 1089196-67-7 C₂₁H₂₀FN₃O₃S 
• 1089196-76-8 C₂₁H₂₀ClN₃O₃S 
• 1089196-79-1 C₂₁H₂₀BrN₃O₃S 
• 1196966-89-8 C₂₂H₂₀N₄O₃S 
• 1029016-04-3 C₂₁H₂₀BrN₃O₃S 
• 1029016-01-0 C₂₁H₂₀ClN₃O₃S 
• 1029016-59-8 C₂₀H₁₉N₃O₂S 
• 1029015-83-5 C₂₀H₁₉N₃O₂S 
• 1029017-15-9 C₂₃H₂₅N₃O₄S 
• 1029016-60-1 C₂₁H₂₁N₃O₃S 
• 1089196-81-5 C₂₀H₁₈ClN₃O₂S 
• 1029016-97-4 C₂₀H₁₈FN₃O₂S 

Relevant articles and documents

N-Acylhydrazones as inhibitors of PDE10A

Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.

PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease

PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. The compounds have the general structure: wherein m, n, p, x, R, R1, R2, R3, R4, R5, A and B, are defined herein, including pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE 10 in a warm-blooded animal in need of the same.