1029016-97-4Relevant academic research and scientific papers
N-Acylhydrazones as inhibitors of PDE10A
Gage, Jennifer L.,Onrust, Rene,Johnston, Derek,Osnowski, Andrew,MacDonald, Wendy,Mitchell, Lee,ür?gdi, László,Rohde, Alex,Harbol, Kevin,Gragerov, Sasha,Dormán, Gy?rgy,Wheeler, Tom,Florio, Vince,Cutshall, Neil S.
scheme or table, p. 4155 - 4159 (2011/08/10)
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.
