2,3-Disubstituted indoles through the palladium-catalyzed reaction of aryl chlorides with o-alkynyltrifluoroacetanilides
2,3-Disubstituted indoles can be prepared in moderate to excellent yields by reacting readily available o-alkynyltrifluoroacetanilides with aryl chlorides in MeCN at 120°C in the presence of Pd2(dba)3 and Xphos.
Preparation of indoles from o-alkynyltrifluoroacetanilides through the aminopalladation-reductive elimination process
The functionalized pyrrole nucleus contained in the indole system has been assembled via the palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with organic halides/triflates or allyl carbonates. In the presence of carbon monoxide, a three-com
Cacchi, Sandro,Fabrizi, Giancarlo,Parisi, Luca M.
p. 1889 - 1894
(2007/10/03)
2-Substituted 3-aryl- and 3-heteroarylindoles by the palladium-catalyzed reaction of o-trifluoroacetanilides with aryl bromides and triflates
The palladium-catalyzed reaction of aryl and heteroaryl bromides and triflates with o-alkynyltrifluoroacetanilides affords 2-substituted 3-aryl- and heteroarylindoles usually in excellent yield. The procedure can be applied to the synthesis of 2-substituted indole-3-carboxaldehydes.
Cacchi, Sandro,Fabrizi, Giancarlo,Lamba, Doriano,Marinelli, Fabio,Parisi, Luca M.
p. 728 - 734
(2007/10/03)
More Articles about upstream products of 91025-04-6