91025-04-6

Basic information

• Product Name: 2-phenyl-3-(pyridin-2-yl)-1H-indole
• Synonyms: 1H-indole, 2-phenyl-3-(2-pyridinyl)-; 2-Phenyl-3-(pyridin-2-yl)-1H-indole
• CAS NO: 91025-04-6
• Molecular Formula: C₁₉H₁₄N₂
• Molecular Weight: 270.3279
• Mol File: 91025-04-6.mol

Chemical Properties

• Boiling Point: 462.4°C at 760 mmHg
• Flash Point: 204.5°C
• Density: 1.197g/cm³
• Vapor Pressure: 2.73E-08mmHg at 25°C
• Refractive Index: 1.685
• CAS DataBase Reference: 2-phenyl-3-(pyridin-2-yl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-3-(pyridin-2-yl)-1H-indole(91025-04-6)
• EPA Substance Registry System: 2-phenyl-3-(pyridin-2-yl)-1H-indole(91025-04-6)

Safety Data

• Hazardous Substances Data: 91025-04-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenyl-3-(pyridin-2-yl)-1H-indole is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its structural features allow for the development of compounds with specific biological activities, making it a key component in the creation of new medications.
Used in Drug Discovery:
PPI serves as a building block in drug discovery, providing a foundation for the design and synthesis of novel drug candidates. Its heterocyclic nature and substituents enable the exploration of different chemical modifications to enhance pharmacological properties.
Used in Biochemical Research:
2-Phenyl-3-(pyridin-2-yl)-1H-indole is utilized as a fluorescent probe in biochemical studies. Its fluorescent properties allow researchers to track and visualize molecular interactions, cellular processes, and other biological phenomena, contributing to a deeper understanding of biological systems.
Used in Chemical Synthesis:
PPI is employed as a key component in the synthesis of complex organic molecules. Its reactivity and structural attributes make it suitable for use in organic reactions, facilitating the production of a variety of chemical compounds for different applications.

Upstream product

• 7647-01-0 hydrogenchloride 
• 91025-03-5 1-phenyl-2-[2]pyridyl-ethanone-phenylhydrazone 
• 7732-18-5 water 
• 109-04-6 2-bromo-pyridine 
• 143360-89-8 o-(phenylethynyl)trifluoroacetanilide 
• 615-43-0 2-iodophenylamine 
• 536-74-3 phenylacetylene 
• 13141-38-3 2-phenylethynylaniline 
• 109-09-1 2-chloropyridine 

Downstream Products

• 42471-56-7 2-(2-aminobenzoyl)pyridine 
• 91025-05-7 benzoic acid-[2-(pyridine-2-carbonyl)-anilide] 

Relevant articles and documents

2,3-Disubstituted indoles through the palladium-catalyzed reaction of aryl chlorides with o-alkynyltrifluoroacetanilides

2,3-Disubstituted indoles can be prepared in moderate to excellent yields by reacting readily available o-alkynyltrifluoroacetanilides with aryl chlorides in MeCN at 120°C in the presence of Pd2(dba)3 and Xphos.

Preparation of indoles from o-alkynyltrifluoroacetanilides through the aminopalladation-reductive elimination process

The functionalized pyrrole nucleus contained in the indole system has been assembled via the palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with organic halides/triflates or allyl carbonates. In the presence of carbon monoxide, a three-com

2-Substituted 3-aryl- and 3-heteroarylindoles by the palladium-catalyzed reaction of o-trifluoroacetanilides with aryl bromides and triflates

The palladium-catalyzed reaction of aryl and heteroaryl bromides and triflates with o-alkynyltrifluoroacetanilides affords 2-substituted 3-aryl- and heteroarylindoles usually in excellent yield. The procedure can be applied to the synthesis of 2-substituted indole-3-carboxaldehydes.