911466-96-1

Basic information

• Product Name: 2,4-Thiazoledicarboxylic acid,2-ethyl ester
• Synonyms: 2,4-Thiazoledicarboxylic acid,2-ethyl ester;2-(Ethoxycarbonyl)thiazole-4-carboxylic acid;2-(Ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid
• CAS NO: 911466-96-1
• Molecular Formula: C₇H₇NO₄S
• Molecular Weight: 201.2
• Mol File: 911466-96-1.mol

Chemical Properties

• Boiling Point: 373.5±34.0 °C(Predicted)
• Appearance: /
• Density: 1.446
• Storage Temp.: 2-8°C
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: 2,4-Thiazoledicarboxylic acid,2-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Thiazoledicarboxylic acid,2-ethyl ester(911466-96-1)
• EPA Substance Registry System: 2,4-Thiazoledicarboxylic acid,2-ethyl ester(911466-96-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 911466-96-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Thiazoledicarboxylic acid, 2-ethyl ester serves as a crucial intermediate in the synthesis of pharmaceuticals. Its chemical structure allows for the development of new drugs, potentially leading to advancements in medicinal chemistry and therapeutic applications.
Used in Agricultural Chemicals:
In the agricultural sector, 2,4-Thiazoledicarboxylic acid,2-ethyl ester is utilized as an intermediate for the production of various agricultural chemicals. Its involvement in this process supports the creation of products that can enhance crop protection and yield.
Used in Dye and Pigment Production:
2,4-Thiazoledicarboxylic acid, 2-ethyl ester is also employed as a chemical intermediate in the manufacturing of dyes and pigments. Its contribution to this industry is essential for the development of a wide range of colorants used in various applications, including textiles, plastics, and printing inks.
Safety and Handling:
Given its potential to cause skin and eye irritation, it is imperative to handle 2,4-Thiazoledicarboxylic acid, 2-ethyl ester with care. Proper safety measures should be adhered to during its storage, use, and disposal to minimize risks to human health and the environment. Compliance with safety regulations is essential to ensure the safe and effective use of this chemical compound in various industries.

Upstream product

• 928716-12-5 ethyl thiooxamate 
• 1113-59-3 bromopyruvic acid 
• 16982-21-1 ethyl 2-amino-2-thioxoacetate 
• 40235-67-4 diethyl thiazole-2,4-dicarboxylate 

Downstream Products

• 1023594-54-8 4-tert-butyl 2-ethyl thiazole-2,4-dicarboxylate 
• 1029432-03-8 4-(tert-butoxycarbonyl)thiazole-2-carboxylic acid 

Relevant articles and documents

NOVEL INDAZOLE COMPOUND OR SALT THEREOF

An indazole compound represented by the following Formula (I) or a salt thereof: wherein X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this specification.

ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C

A method of treating cancer comprises administering: (a) a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof; and (b) a therapeutically effective amount of an additional anti-cancer agent, to a subject in need of such treatment, the compound of Formula (I) being: where X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this disclosure.

METHODS OF TREATING CANCER

The present disclosure relates to methods of treating cancer in a patient using a combination of an inhibitor of an immune checkpoint protein and an indole compound or its phosphate derivative.

INDOLE COMPOUNDS AND THEIR USE

The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.

NOVEL FERROPORTIN INHIBITORS

The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.

6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT

The present invention comprises compounds of Formula I. wherein: A1, A2, A3, A4, A5, R1, and R2 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Design and synthesis of thiazole and thiazolidine metallo-supramolecular networks

A mild and selective procedure for the synthesis of 4-carboxy thiazoles and thiazolidines starting from naturally occurring cysteine by condensation with aldehydes is described. The optimized procedure, taking advantage of the positive effect of microwave

DIAMIDO THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to novel Diamido Thiazole Derivatives of structure I, compositions comprising the Diamido Thiazole Derivatives, and methods for using the Diamido Thiazole Derivatives for treating or preventing a proliferative disorder, an anti -proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase. Formula (I) wherein: M is -C(O)-, -C(S)-. -S(O)-. -S(O)2-. -NHS(O)2-. -OC(O)- or -NHC(O)-; Q is:formula (II).

ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.