912848-91-0Relevant academic research and scientific papers
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure-activity relationships
Powell, Dennis,Gopalsamy, Ariamala,Wang, Yanong D.,Zhang, Nan,Miranda, Miriam,McGinnis, John P.,Rabindran, Sridhar K.
, p. 1641 - 1645 (2007/10/03)
A novel series of antiproliferative agents containing pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides, selective for p21-deficient cells, were identified by high-throughput screening. Exploration of the SAR relationships in the headpiece, core, and tailpiece
PROCESS FOR PREPARING BICYCLIC COMPOUNDS
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Page/Page column 32-33, (2008/06/13)
The present invention relates to a novel process for preparing compounds of formula (IA), which are potent and specific antagonists of corticotropin-releasing factor (CRF) receptors, from intermediate compounds of formula (I), by a coupling reaction catal
Thiazole compounds useful as inhibitors of protein kinase
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, (2008/06/13)
The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also
