- NMDA receptor antagonist and use thereof
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The present invention relates to an NMDA receptor antagonist and use thereof. The NMDA receptor antagonist is a compound as shown in the formula I, and pharmaceutically acceptable salts, enantiomers, diastereoisomers, tautomers, solvates, isotope substitutes, polymorphic substances, prodrugs or metabolites thereof, and in the formula, ring A, ring B and R2 are as described in the specification. The invention also provides pharmaceutical compositions containing the compounds, and applications of the compounds in preparation of drugs for treating or preventing NMDA receptor mediated diseases.
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Paragraph 0367-0371
(2021/08/11)
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- p-Toluenesulfonic acid catalysed fluorination of α-branched ketones for the construction of fluorinated quaternary carbon centres
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A p-toluenesulfonic acid catalyzed fluorination of α-branched ketones for the construction of fluorinated quaternary carbon centers has been developed, featuring a broad substrate scope, environmentally benign reaction conditions, and operational simplicity.
- Tang, Shi-Zhong,Bian, Hong-Li,Zhan, Zong-Song,Chen, Meng-En,Lv, Jian-Wei,Xie, Shaolei,Zhang, Fu-Min
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supporting information
p. 12377 - 12380
(2018/11/30)
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- Intermediate compound for synthesizing ketamine and method for synthesizing ketamine
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The invention discloses an intermediate compound for synthesizing ketamine, having a chemical structural formula shown in the specification. The intermediate compound is prepared by: (i) reacting o-chlorobromobenzene and lithium alkylide to obtain lithium o-chlorophenyl; (ii) reacting the lithium o-chlorophenyl and cyclohexene oxide under the action of Lewis acid. The intermediate compound may be oxidized, nitrified, nitro-reduced and then amino-methylated to produce ketamine. Compared with existing synthetic methods of ketamine, the method of the invention has simple route, low cost and good operation convenience.
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Paragraph 0043; 0046; 0047
(2017/08/28)
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- Palladium-catalysed intramolecular enolate O-arylation and thio-enolate S-arylation: synthesis of benzo[b]furans and benzo[b]thiophenes
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Enolates derived from α-(ortho-haloaryl)-substituted ketones undergo palladium-catalysed C-O bond formation to deliver benzofuran products in good yield. A catalyst generated from Pd2(dba)3 and the ligand DPEphos effects the key bond
- Willis, Michael C.,Taylor, Dawn,Gillmore, Adam T.
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p. 11513 - 11520
(2007/10/03)
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- Palladium-catalyzed intramolecular O-arylation of enolates: Application to benzo[6]furan synthesis
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(Chemical Equation Presented) A catalyst generated from Pd 2(dba)3 and the ligand DPEphos effects intramolecular C-O bond formation between enolates and aryl halides in the conversion of 1-(2-haloaryl)ketones directly into the corres
- Willis, Michael C.,Taylor, Dawn,Gillmore, Adam T.
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p. 4755 - 4757
(2007/10/03)
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