914208-13-2

Basic information

• Product Name: 8-FLUOROQUINOLINE-2-CARBOXYLIC ACID
• Synonyms: 8-FLUOROQUINOLINE-2-CARBOXYLIC ACID;AKOS A0602-0955;8-fluoroquinoline-2-carboxylic acid(SALTDATA: FREE)
• CAS NO: 914208-13-2
• Molecular Formula: C₁₀H₆FNO₂
• Molecular Weight: 191.1585432
• Mol File: 914208-13-2.mol

Chemical Properties

• Boiling Point: 352.1°C at 760 mmHg
• Flash Point: 166.8°C
• Appearance: /
• Density: 1.431g/cm³
• Vapor Pressure: 1.45E-05mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: 2-8°C
• PKA: 3.52±0.30(Predicted)
• CAS DataBase Reference: 8-FLUOROQUINOLINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUOROQUINOLINE-2-CARBOXYLIC ACID(914208-13-2)
• EPA Substance Registry System: 8-FLUOROQUINOLINE-2-CARBOXYLIC ACID(914208-13-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 914208-13-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-Fluoroquinoline-2-carboxylic acid is used as an active pharmaceutical ingredient for the development of antimicrobial drugs. Its potent antibacterial properties make it effective against a wide range of bacterial infections, including those caused by gram-negative and gram-positive bacteria.
Used in Research and Development:
8-Fluoroquinoline-2-carboxylic acid serves as a key compound in the research and development of new antibiotics. Scientists are exploring its potential applications in the treatment of drug-resistant bacterial strains and investigating its mechanism of action to enhance its efficacy and minimize side effects.
Used in Drug Synthesis:
As a building block in the synthesis of various pharmaceutical drugs, 8-Fluoroquinoline-2-carboxylic acid is used to create novel fluoroquinolone antibiotics with improved properties, such as increased potency, better bioavailability, and reduced toxicity.
Used in Veterinary Medicine:
8-Fluoroquinoline-2-carboxylic acid is also utilized in veterinary medicine as an antimicrobial agent for the treatment of bacterial infections in animals. Its broad-spectrum activity makes it suitable for treating various bacterial infections in livestock and pets.

InChI:InChI=1/C10H6FNO2/c11-7-3-1-2-6-4-5-8(10(13)14)12-9(6)7/h1-5H,(H,13,14)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 46001-36-9 8-fluoro-2-methylquinoline 

Relevant articles and documents

Synthesis of palladium complexes with quinolino-based tridentate ligands and their applications for norbornene polymerization

Palladium complexes bearing new tridentate quinolino-based [N?NNox] ligands were synthesized and tested for the polymerization of norbornene. Upon activation of MAO, all the palladium complexes showed high catalytic activities for th

Oxidant-free synthesis of benzimidazoles from alcohols and aromatic diamines catalysed by new Ru(II)-PNS(O) pincer complexes

Benzimidazoles are chemically and pharmaceutically important, and an environmentally benign synthetic method based on acceptorless dehydrogenative condensation of primary alcohols and benzene-1,2-diamine is developed in this work. Three Ru(ii) hydride complexes [RuHCl(CO)(PNS(O))] (containing two isomers 1a and 1b) and [RuHCl(CO)(PPh3)(SNCNHC)]PF6 (2) based on two new quinoline-based ligands 2-(diphenylphosphanylmethyl)-8-phenylsulfinylquinoline (PNS(O)) and 1-mesityl-3-(8-phenylthioquinolyl-2-methyl)-2-imidazole carbene (SNCNHC) are prepared and fully characterized. These complexes catalyse the condensation of benzyl alcohol and benzene-1,2-diamine to 2-phenylbenzimidazole with the liberation of H2, and the catalytic activity follows the order: 1a ≈ 1b > 2. When 0.2 mol% of 1a and 2 mol% of NaBPh4 were used, various 2-functionalized benzimidazoles were obtained in good yields (70-85%) and high turnover numbers (TONs ～ 425). This homogeneous system does not need oxidants or stoichiometric strong bases (KOH or KOtBu, etc.) that are normally used in the reported homogeneous systems, and thus is a greener process.