Studies on the total synthesis of lactonamycin: Synthesis of the CDEF ring system
A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel-Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core struct
Wehlan, Hermut,Jezek, Eva,Lebrasseur, Nathalie,Pave, Gregoire,Roulland, Emmanuel,White, Andrew J. P.,Burrows, Jeremy N.,Barrett, Anthony G. M.
p. 8151 - 8158
(2007/10/03)
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