- Photoinduced DNA Interstrand Cross-Linking by Benzene Derivatives: Leaving Groups Determine the Efficiency of the Cross-Linker
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We have synthesized and characterized two small libraries of 2-OMe or 2-NO2-benzene analogues 2a-i and 3a-i containing a wide variety of leaving groups. Irradiation of these compounds at 350 nm generated benzyl radicals that were spontaneously oxidized to
- Fan, Heli,Peng, Xiaohua
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p. 493 - 506
(2020/12/22)
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- SOD activity and DNA binding properties of a new symmetric porphyrin Schiff base ligand and its metal complexes
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4-Methoxy-2,6-bis(hydroxymethyl)phenol (1) was prepared from the reaction of 4-methoxyphenol and formaldehyde. The compound (1) was then oxidized to the 4-methoxy-2,6-diformylphenol (2) compound. Molecular structure of compound (2) was determined by X-ray
- ?ay, Sevim,K?se, Muhammet,Tümer, Ferhan,G?lcü, Ay?egül,Tümer, Mehmet
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p. 821 - 838
(2015/07/20)
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- Coordination cluster analogues of the high-Spin [Mn19] system with functionalized 2,6-Bis(hydroxymethyl)phenol ligands
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A series of 2,6-bis(hydroxymethyl)-4-R-phenol ligands (H3LR; R = H, F, Cl, Br, I, Ph, NH2, NO2, SMe) have either been newly synthesized or the existing syntheses have been significantly improved to investigate ligand-functionalized analogues of the previously published coordination cluster [MnIII12MnII7(μ4-O)8(μ3-N3)8(HLMe)12(MeCN)6]Cl2·10MeOH·MeCN (1) with S = 83/2. The crystal structures and magnetic properties of three such Mn19 clusters, namely, [MnIII12MnII7(μ4-O)8(HLH)12(μ3-Cl)7(μ3-OMe)(MeOH)6]Cl2·16H2O·10MeOH·MeCN (3), [MnIII12MnII7(μ4-O)8(HLI)12(μ3-N3)8(MeOH)6](O2CH)2·16MeOH·10MeCN (4) and [MnIII12MnII7(μ4-O)8(μ3-Cl)7.7(μ3-OMe)0.3(HLSMe)12(MeOH)6]Cl2·27MeOH (5) are reported and compared to those of the parent cluster. When these ligands are functionalized with substituents of moderate electronegativity, it is possible to synthesize Mn19 analogues; however, when such ligands bear highly electron-donating (amino) or -withdrawing (nitro) substituents, the Mn19 analogues are no longer accessible. The Mn19 cluster framework is both magnetically and structurally robust with respect to the electron-donor/acceptor characteristics of the ligand substituent; therefore, the Mn19 system is an excellent platform for peripheral chemical engineering. The robustness of the inorganic {MnIII12MnII7(μ4-O)8} core of Mn19 systems with variously functionalized encapsulating ligands is demonstrated by the invariance of the record S = 83/2 spin state. Chemical modification aimed towards attaching the molecule to various substrates does not interfere with the electronic structure.
- Mameri, Samir,Ako, Ayuk M.,Yesil, Fatma,Hibert, Marcel,Lan, Yanhua,Anson, Christopher E.,Powell, Annie K.
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p. 4326 - 4334
(2015/03/30)
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- Studies on the total synthesis of lactonamycin: Synthesis of the fused pentacyclic B-F ring unit
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This paper describes an approach towards the total synthesis of lactonamycin with the elaboration of a key pentacyclic unit. Key steps include the synthesis of benzyl bromide 8 in eight steps and 23 % overall yield starting from 4-methoxyphenol; a high-yi
- Jacques, Sylvain A.,Michaelis, Simon,Gebhardt, Bjoern,Blum, Andreas,Lebrasseur, Nathalie,Larrosa, Igor,White, Andrew J. P.,Barrett, Anthony G. M.
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experimental part
p. 107 - 113
(2012/01/15)
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- UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS
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Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.
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- UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS
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Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.
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Page/Page column 11
(2010/06/11)
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- Studies on the total synthesis of lactonamycin: Synthesis of the CDEF ring system
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A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel-Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core struct
- Wehlan, Hermut,Jezek, Eva,Lebrasseur, Nathalie,Pave, Gregoire,Roulland, Emmanuel,White, Andrew J. P.,Burrows, Jeremy N.,Barrett, Anthony G. M.
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p. 8151 - 8158
(2007/10/03)
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- Towards a total synthesis of the new anticancer agent mensacarcin: Synthesis of the carbocyclic core
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A synthesis of the carbocyclic core associated with the new anti-cancer agent mensacarcin (1) is reported. The strategy involves the synthesis of several novel highly substituted aromatic compounds, such as 12 and 23. The lithium derivative of 12 readily
- Tietze, Lutz F.,Stewart, Scott G.,Polomska, Marta E.,Modi, Andrea,Zeeck, Axel
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p. 5233 - 5242
(2007/10/03)
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- Dinuclear zinc(II)-iron(III) and iron(II)-iron(III) complexes as models for purple acid phosphatases
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The heterodinuclear ZnIIFeIII complex 1 and the isostructural FeIIFeIII complex 2 with the dinucleating ligand from 2,6-bis[{bis(2-pyridylmethyl)amino}methyl]-4-methoxyphenol (HBPMOP, 3) were prepared and charac
- Albedyhl, Sabine,Averbuch-Pouchot, Marie Therese,Belle, Catherine,Krebs, Bernt,Pierre, Jean Louis,Saint-Aman, Eric,Torelli, Stephane
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p. 1457 - 1464
(2007/10/03)
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