- Synthesis method of imidacloprid metabolite 5-hydroxyimidacloprid
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The invention discloses a synthesis method of an imidacloprid metabolite 5-hydroxyimidacloprid, and belongs to the field of medicine synthesis. According to the synthesis method, methyl 5-hydroxynicotinate is used as a raw material, synthesis of the imidacloprid metabolite 5-hydroxylimidacloprid is achieved for the first time through six-step reaction, an optimal synthesis route and reaction conditions are screened out through a large number of experiments, the purity of the prepared target product can reach 99% or above, and the target product does not contain raw material medicine imidacloprid can be used for research on pharmacokinetics, raw material medicine impurity identification, environment control and protection and the like, provides a sample for impurity identification of imidacloprid, metabolic mechanism research, influence on the environment after medicine use, how to carry out corresponding protection and the like, and has important application value.
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- TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
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The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.
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- NOVEL HETEROARYL IMIDAZOLES AND HETEROARYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS
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Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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- BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 065
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The invention provides compounds of formula wherein R1, R2, R3, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1
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Page/Page column 66
(2009/05/28)
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- BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066
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The invention provides compounds of formula wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.
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Page/Page column 140
(2009/06/27)
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- Multi-substituted pyridyl sulfoximines and their use as insecticides
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Multi-substituted pyridyl sulfoximines are useful as insecticides.
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Page/Page column 10
(2008/12/04)
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