915107-30-1

Basic information

• Product Name: 6-Chloro-5-hydroxy-nicotinic acid methyl ester
• Synonyms: 6-Chloro-5-hydroxy-nicotinic acid methyl ester
• CAS NO: 915107-30-1
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 188
• EINECS: 604-604-1
• Mol File: 915107-30-1.mol

Chemical Properties

• Melting Point: 142-143 °C(Solv: water (7732-18-5))
• Boiling Point: 383.796°C at 760 mmHg
• Flash Point: 185.914°C
• Appearance: /
• Density: 1.433g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.61±0.10(Predicted)
• CAS DataBase Reference: 6-Chloro-5-hydroxy-nicotinic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-hydroxy-nicotinic acid methyl ester(915107-30-1)
• EPA Substance Registry System: 6-Chloro-5-hydroxy-nicotinic acid methyl ester(915107-30-1)

Safety Data

• Hazardous Substances Data: 915107-30-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-5-hydroxy-nicotinic acid methyl ester is used as a synthetic intermediate for the production of 5-Hydroxy-Imidacloprid (H943220), a metabolite of Imidacloprid (I274990). Imidacloprid is an active ingredient in certain neuro-active insecticides, making this ester a crucial component in the development and synthesis of effective pest control agents.

InChI:InChI=1/C7H6ClNO3/c1-12-7(11)4-2-5(10)6(8)9-3-4/h2-3,10H,1H3

Upstream product

• 30766-22-4 methyl 5-hydroxy-3-pyridinecarboxylate 
• 100-39-0 benzyl bromide 

Downstream Products

• 915107-39-0 6-chloro-5-methoxynicotinic acid 
• 915107-31-2 methyl 6-chloro-5-methoxypyridine-3-carboxylate 
• 1415110-11-0 C₁₇H₁₇NO₄ 
• 1415110-12-1 C₁₇H₁₈N₂O₄ 
• 1415110-14-3 C₁₇H₁₆N₂O₃ 
• 1415110-10-9 methyl 5-(benzyloxy)-6-chloronicotinate 
• 380912-09-4 5-hydroxy imidacloprid 

Relevant articles and documents

Synthesis method of imidacloprid metabolite 5-hydroxyimidacloprid

The invention discloses a synthesis method of an imidacloprid metabolite 5-hydroxyimidacloprid, and belongs to the field of medicine synthesis. According to the synthesis method, methyl 5-hydroxynicotinate is used as a raw material, synthesis of the imidacloprid metabolite 5-hydroxylimidacloprid is achieved for the first time through six-step reaction, an optimal synthesis route and reaction conditions are screened out through a large number of experiments, the purity of the prepared target product can reach 99% or above, and the target product does not contain raw material medicine imidacloprid can be used for research on pharmacokinetics, raw material medicine impurity identification, environment control and protection and the like, provides a sample for impurity identification of imidacloprid, metabolic mechanism research, influence on the environment after medicine use, how to carry out corresponding protection and the like, and has important application value.

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