916179-88-9

Basic information

• Product Name: Methyl 3-Bromoindole-5-carboxylate
• Synonyms: Methyl 3-Bromoindole-5-carboxylate;3-Bromoindole-5-carboxylic acid methyl ester;Methyl 3-broMo-1H-indole-5-carboxylate
• CAS NO: 916179-88-9
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.08002
• Mol File: 916179-88-9.mol

Chemical Properties

• Appearance: /
• Density: 1.629
• CAS DataBase Reference: Methyl 3-Bromoindole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-Bromoindole-5-carboxylate(916179-88-9)
• EPA Substance Registry System: Methyl 3-Bromoindole-5-carboxylate(916179-88-9)

Safety Data

• Hazardous Substances Data: 916179-88-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Methyl 3-Bromoindole-5-carboxylate is used as a building block in organic synthesis for the creation of other compounds. Its unique structural properties and reactivity allow for the development of a wide range of chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Methyl 3-Bromoindole-5-carboxylate is utilized as a key intermediate in the synthesis of various drug candidates. Its potential applications in medicinal chemistry and drug development are attributed to its ability to be modified and incorporated into novel therapeutic agents.
Used in Medicinal Chemistry:
Methyl 3-Bromoindole-5-carboxylate is employed in medicinal chemistry as a structural component of potential drug molecules. Its reactivity and compatibility with other chemical groups make it a versatile component in the design and synthesis of new pharmaceuticals.
Used in Drug Development:
In the field of drug development, Methyl 3-Bromoindole-5-carboxylate serves as a precursor in the synthesis of compounds with potential therapeutic applications. Its role in the development of new drugs is crucial, as it can be modified to enhance the pharmacological properties of the final product.

Upstream product

• 916179-87-8 3-bromo-1H-indole-5-carboxylic acid 
• 74-88-4 methyl iodide 
• 1011-65-0 5-methoxycarbonylindole 

Downstream Products

• 916179-86-7 3-bromo-1-(toluene-4-sulfonyl)-indole-5-carboxylic acid methyl ester 
• 1160437-40-0 methyl 3-phenyl-1H-indole-5-carboxylate 

Relevant articles and documents

A Palladium(II)-Catalyzed C-H Activation Cascade Sequence for Polyheterocycle Formation

Polyheterocycles are found in many natural products and are useful moieties in functional materials and drug design. As part of a program towards the synthesis of Stemona alkaloids, a novel palladium(II)-catalyzed C-H activation strategy for the construction of such systems has been developed. Starting from simple 1,3-dienyl-substituted heterocycles, a large range of polycyclic systems containing pyrrole, indole, furan and thiophene moieties can be synthesized in a single step. Don't overdo it: A palladium(II)-catalyzed C-H activation cascade sequence for the synthesis of polyheterocycles is reported. Aromatization of the initially formed dihydro species occurred with a quinone oxidant. In some cases the use of one equivalent of the oxidant enabled isolation of the dihydro species as a single isomer (see scheme; X=NMe, O, S).

INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS

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OXADIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

Oxadiazole derivatives of formula (I) where ring A is a bicyclic or tricyclic system. Claimed compounds are active on nicotinic acetylcholine receptors (nAChRs), and are useful to treat neurological, psychiatric, and gastrointestinal disorders, as well as sepsis and obesity.

TREATMENT OF PROTEIN FOLDING DISORDERS

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