1011-65-0Relevant articles and documents
Electrochemical esterification via oxidative coupling of aldehydes and alcohols
Smeyne, Dylan,Verboom, Katherine,Bryan, Maria,LoBue, James,Shaikh, Abid
, (2021)
An electrolytic method for the direct oxidative coupling of aldehydes with alcohols to produce esters is described. Our method involves anodic oxidation in presence of TBAF as supporting electrolyte in an undivided electrochemical cell equipped with graphite electrodes. This method successfully couples a wide range of alcohols to benzaldehydes with yields ranging from 70 to 90%. The protocol is easy to perform at a constant voltage conditions and offers a sustainable alternative over conventional methods.
Bartoli indole synthesis on solid supports
Knepper, Kerstin,Braese, Stefan
, p. 2829 - 2832 (2003)
(Matrix presented) Bartoli indole synthesis has been performed for the first time on solid supports. Starting from Merrifield resin, immobilization of five nitro benzoic acids was performed. Addition of four different alkenyl Grignard reagents and basic c
Palladium-Catalyzed, Copper(I)-Promoted Methoxycarbonylation of Arylboronic Acids with O-Methyl S-Aryl Thiocarbonates
Cao, Ya-Fang,Li, Ling-Jun,Liu, Min,Xu, Hui,Dai, Hui-Xiong
, p. 4475 - 4481 (2020)
Here, we report O-methyl S-aryl thiocarbonates as a versatile esterification reagent for palladium-catalyzed methoxycarbonylation of arylboronic acid in the presence of copper(I) thiophene-2-carboxylate (CuTC). The reaction condition is mild, and a variety of substituents including sensitive-Cl,-Br, and free-NH2 could be tolerated. Further applications in the late-stage esterification of some pharmaceutical drugs demonstrate the broad utility of this method.
A method of synthesis of indole derivatives
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Paragraph 0018-0021, (2022/01/10)
The present invention belongs to the field of indole synthesis technology, in order to solve the current synthesis of indole and its derivatives with ethylene glycol as raw material, the conditions are relatively harsh, the structure of the main catalyst is complex, expensive and other issues, providing a synthesis method of indole derivatives. Pt/Al2O3 catalyst supportingPt/Al2O3was prepared by impregnation with acidicAl2O3as the support, using aniline compounds, ethylene glycol, and the preparedPt/Al2O3 Catalyst for catalytic reaction, control reaction temperature of 190 °C, reaction 24h, after the end of the reaction, first add water to stir evenly, and then with dichloromethane for extraction, organic phase by rotational distillation to remove the solvent, and then with petroleum ether, ethyl acetate as the eluent column chromatography separation, you can obtain the target product. A broad spectrum of the Catalytic System ofPt/Al2O3Supported Catalysts with Good Catalytic Effect inthe Glycol Aniline Reaction was studied, and the substrate range of substituted aniline was mainly expanded.
Visible-Light-Mediated N-Desulfonylation of N-Heterocycles Using a Heteroleptic Copper(I) Complex as a Photocatalyst
Hunter, Cameron J.,Boyd, Michael J.,May, Gregory D.,Fimognari, Robert
, p. 8732 - 8739 (2020/07/16)
A photoredox protocol that uses a heteroleptic Cu (I) complex, [Cu(dq)(BINAP)]BF4, has been developed for the photodeprotection of benzenesulfonyl-protected N-heterocycles. A range of substrates was examined, including indazoles, indoles, pyrazoles, and benzimidazole, featuring both electron-rich and electron-deficient substituents, giving good yields of the N-heterocycle products with broad functional group tolerance. This transformation was also found to be amenable to flow reaction conditions.
