91675-96-6

Basic information

• Product Name: (S,1,4)-AMINO-4-HYDROXY-CYCLOHEXANEACETIC ACID
• Synonyms: (S,1,4)-AMINO-4-HYDROXY-CYCLOHEXANEACETIC ACID
• CAS NO: 91675-96-6
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.21
• Mol File: 91675-96-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S,1,4)-AMINO-4-HYDROXY-CYCLOHEXANEACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S,1,4)-AMINO-4-HYDROXY-CYCLOHEXANEACETIC ACID(91675-96-6)
• EPA Substance Registry System: (S,1,4)-AMINO-4-HYDROXY-CYCLOHEXANEACETIC ACID(91675-96-6)

Safety Data

• Hazardous Substances Data: 91675-96-6(Hazardous Substances Data)

Upstream product

• 6324-01-2 p-hydroxyphenylglycine 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 32462-30-9 (S)-hydroxyphenylglycine 

Downstream Products

• 130624-89-4 trans-(D)-N^α-(Boc)-4-hydroxycyclohexylglycine 
• 130624-89-4 cis-(D)-N^α-(Boc)-4-hydroxycyclohexylglycine 
• 130624-90-7 trans-(D)-N^α-(Boc)-4-hydroxycyclohexylglycine benzyl ester 
• 130624-90-7 cis-(D)-N^α-(Boc)-4-hydroxycyclohexylglycine benzyl ester 
• 91675-87-5 2-Benzamido-2-(4-hydroxycyclohexyl)acetic Acid 

Relevant articles and documents

ALPHA-AMINO ACID DERIVATIVES AND USE THEREOF AS MEDICINES

Compounds represented by the α-amino acid derivative or a pharmaceutically acceptable salt thereof of the present invention have a therapeutic effect due to a DPP-IV inhibitory action and useful as pharmaceutical agents for the treatment and/or prophylaxi

Carbocyclic side chain containing, N-substituted metalloprotease inhibitors

The compounds have a structure according to the following Formula (I): are effective in treating conditions characterized by excess activity of metalloprotease enzymes.

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

A series of carboxylic acids was prepared based on cyclohexylglycine scaffolds and tested for potency as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for five enzymes within the MMP family, and a number of inhibitors such as compound 18 display low nanomolar potency for MMP-2 and MMP-13, while selectively sparing MMP-1 and MMP-7.

Synthesis of Optically Pure Analogue of D-Arginine Methyl Ester with Antiarrhythmic Activity

The synthesis of the methyl esters of optically pure trans and cis 4-guanidinocyclohexylglycine as rigid analogues of D-arginine methyl ester are described.

STEREOISOMERIC CHIRAL 2,9-DIAZABICYCLODECANE-3,10-DIONES AS MODELS OF DIPEPTIDE GROUPING: SYNTHESIS, X-RAY, IR, NMR AND CD STUDIES

Synthesis of the title optically active bicyclic dilactams I and II with cis- and trans-annelation of rings is described.The stereospecific synthesis started from (2R)-2-benzamido-2-(4-oxocyclohexyl)acetic acid ((-)-VI) whose absolute configuration was de