6324-01-2

Basic information

• Product Name: 2-amino-2-(4-hydroxyphenyl)acetic acid
• Synonyms: (1)-4-Hydroxyphenylglycine;Einecs 228-682-7
• CAS NO: 6324-01-2
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 0
• EINECS: 228-682-7
• Mol File: 6324-01-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 365.8°C at 760 mmHg
• Flash Point: 175°C
• Appearance: /
• Density: 1.396g/cm³
• Vapor Pressure: 5.4E-06mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: 2-amino-2-(4-hydroxyphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-2-(4-hydroxyphenyl)acetic acid(6324-01-2)
• EPA Substance Registry System: 2-amino-2-(4-hydroxyphenyl)acetic acid(6324-01-2)

Safety Data

• Hazardous Substances Data: 6324-01-2(Hazardous Substances Data)

Usage

General Description

2-amino-2-(4-hydroxyphenyl)acetic acid is an organic compound with the chemical formula C8H9NO3. It is a derivative of the simple amino acid tyrosine, where an amine group is attached to the carbon adjacent to the carboxyl group. 2-amino-2-(4-hydroxyphenyl)acetic acid is also known as 4-hydroxyphenylglycine or noradrenaline. It is an important intermediate in the biosynthesis of the neurotransmitters dopamine, norepinephrine, and epinephrine, which play crucial roles in regulating mood, stress response, and blood pressure. Additionally, this compound has potential pharmaceutical applications due to its role in neurotransmission and its ability to affect the central nervous system.

InChI:InChI=1/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)

Upstream product

• 151-50-8 potassium cyanide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 2835-06-5 phenylglycin 
• 42456-26-8 2-amino-2-(4-methoxyphenyl)acetonitrile 
• 64923-06-4 D-p-hydroxyphenylglycine o-toluenesulfonate 
• 15573-67-8 pisolithin A 
• 99-93-4 4-Hydroxyacetophenone 
• 2420-17-9 5-(4-hydroxy-phenyl)-imidazolidine-2,4-dione 
• 43189-12-4 (R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate 
• 26787-78-0 amoxicillin 
• 298-12-4 Glyoxilic acid 
• 108-95-2 phenol 
• 123-11-5 4-methoxy-benzaldehyde 
• 160219-64-7 chloropeptin I 

Downstream Products

• 111273-30-4 4-(2-phenyl-1⁽³⁾H-imidazol-4-yl)-phenol 
• 55399-86-5 benzoylamino-(4-hydroxy-phenyl)-acetic acid 
• 101252-25-9 2-Amino-2-(4-hydroxycyclohexyl)acetic acid 
• 123621-16-9 amino-(3,5-dibromo-4-hydroxy-phenyl)-acetic acid 
• 43189-12-4 (R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate 
• 26531-82-8 (S)-methyl 2-amino-2-(4-hydroxyphenyl)acetate 
• 43189-09-9 2-(p-Hydroxyphenyl)glycine Ethyl Ester 
• 43189-38-4 (R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate 
• 37784-25-1 N-acetyl-(RS)-2-(4-hydroxyphenyl)glycine 
• 37784-23-9 N-acetyl-(R)-2-(4-hydroxyphenyl)glycine 
• 938-97-6 D-(4-hydroxyphenyl)glycine 
• 72500-37-9 α-(aminocarbonyl)amino-4-hydroxybenzeneacetic acid 
• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 
• 169512-95-2 methyl (S)-2-((tert-butoxycarbonyl)amino)-2-cyclohexylacetate 

Relevant articles and documents

Method for preparing p-hydroxyphenylglycine in pulse tubular reactor

The invention discloses a method for preparing p-hydroxyphenylglycine in a pulse tubular reactor, which is characterized in that glyoxylic acid, phenol and sulfamic acid are used as raw materials, p-hydroxyphenylglycine is prepared in a novel pulse tubular reactor in a nitrogen atmosphere, and the method belongs to the technical field of organic synthesis processes. Materials are introduced into the pulse tubular reactor through a metering pump and then subjected to preheating, mixing reaction and separation to obtain a p-hydroxyphenylglycine product, and compared with a process reported in literatures, the novel process has the advantages that the reaction time can be greatly shortened, the workshop efficiency can be improved, the reaction temperature can be accurately controlled, and the generation of by-products can be effectively reduced. And by introducing the novel pulse reactor, the mass and heat transfer effect of the reaction is qualitatively improved compared with that of a kettle type process, so that the use of a phase transfer catalyst is avoided, and the cost is saved. Compared with methods reported in literatures, the process technology has the advantages that the glyoxylic acid conversion rate, the product selectivity and the like are remarkably improved, and the existing outdated process technology can be replaced after the process technology is put into production.

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

P-hydroxy-glycine preparation method (by machine translation)

The invention provides a method for the preparation of hydroxy-phenyl glycine, comprising the following steps: A synthetic hydroxy because benzene sea, B. Hydroxyphenyl hydantoin as a result of the hydrolysis, the present invention provides a preparation method, high efficiency, high output, suitable for large-scale mass production. (by machine translation)