Organic electroluminescent material and device thereof
Disclosed are an organic electroluminescent material and a device thereof. The organic electroluminescent material is a novel triaryl amine-aza-carbazole quinazoline compound. The compound is used asa host material in an electroluminescent device and prov
-
Paragraph 0126-0129
(2020/09/30)
A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors
The epigenetic regulator CBP/P300 presents a novel therapeutic target for oncology. Previously, we disclosed the development of potent and selective CBP bromodomain inhibitors by first identifying pharmacophores that bind the KAc region and then building into the LPF shelf. Herein, we report the "hybridization" of a variety of KAc-binding fragments with a tetrahydroquinoline scaffold that makes optimal interactions with the LPF shelf, imparting enhanced potency and selectivity to the hybridized ligand. To demonstrate the utility of our hybridization approach, two analogues containing unique Asn binders and the optimized tetrahydroquinoline moiety were rapidly optimized to yield single-digit nanomolar inhibitors of CBP with exquisite selectivity over BRD4(1) and the broader bromodomain family.
Bronner, Sarah M.,Murray, Jeremy,Romero, F. Anthony,Lai, Kwong Wah,Tsui, Vickie,Cyr, Patrick,Beresini, Maureen H.,De Leon Boenig, Gladys,Chen, Zhongguo,Choo, Edna F.,Clark, Kevin R.,Crawford, Terry D.,Jayaram, Hariharan,Kaufman, Susan,Li, Ruina,Li, Yingjie,Liao, Jiangpeng,Liang, Xiaorong,Liu, Wenfeng,Ly, Justin,Maher, Jonathan,Wai, John,Wang, Fei,Zheng, Aijun,Zhu, Xiaoyu,Magnuson, Steven
p. 10151 - 10171
(2018/01/10)
ALKYNYL ALCOHOLS AND METHODS OF USE
The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
-
Paragraph 0575; 0576
(2015/03/04)
ALKYNYL ALCOHOLS AND METHODS OF USE
The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
-
Page/Page column 142
(2015/03/13)
Heterobicyclic amide compounds
Compounds of formula I processes for their preparation and pharmaceutical compositions comprising them.
-
Page/Page column 10
(2010/11/28)
More Articles about upstream products of 91678-23-8