916792-23-9

Basic information

• Product Name: 4-BROMO-2-FLUORO-5-METHYLBENZALDEHYDE
• Synonyms: Benzaldehyde, 4-bromo-2-fluoro-5-methyl-
• CAS NO: 916792-23-9
• Molecular Formula: C8H6BrFO
• Molecular Weight: 217.04
• EINECS: 1533716-785-6
• Mol File: 916792-23-9.mol

Chemical Properties

• Boiling Point: 259.9oC at 760 mmHg
• Flash Point: 111oC
• Appearance: /
• Density: 1.575g/cm3
• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-BROMO-2-FLUORO-5-METHYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-FLUORO-5-METHYLBENZALDEHYDE(916792-23-9)
• EPA Substance Registry System: 4-BROMO-2-FLUORO-5-METHYLBENZALDEHYDE(916792-23-9)

Safety Data

• Hazardous Substances Data: 916792-23-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-2-FLUORO-5-METHYLBENZALDEHYDE is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its antimicrobial and antifungal properties make it a promising candidate for applications in treating infections and diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 4-BROMO-2-FLUORO-5-METHYLBENZALDEHYDE is utilized as a key intermediate in the production of agrochemicals, such as pesticides and fungicides, to protect crops from microbial and fungal infections, thereby enhancing agricultural productivity.
Used in Organic Chemistry Research and Development:
4-BROMO-2-FLUORO-5-METHYLBENZALDEHYDE is employed as a crucial building block in the synthesis of a wide range of organic compounds. Its unique structure and reactivity make it an important reagent in the field of organic chemistry, facilitating the discovery and development of novel chemical entities with potential applications in various industries.

InChI:InChI=1/C8H6BrFO/c1-5-2-6(4-11)8(10)3-7(5)9/h2-4H,1H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 134332-29-9 1,4-dibromo-2-fluoro-5-methylbenzene 
• 78775-11-8 3-methyl-4-bromobenzaldehyde 

Relevant articles and documents

SELECTIVE FLUORESCENT PROBE FOR ALDEHYDE DEHYDROGENASE

High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. Herein, is presented AlDeSense, a turn-on green fluorescent probe for aldehyde dehydrogenase 1A1 (ALDH1A1) and Ctrl-AlDeSense, a matching non-responsive reagent. AlDeSense exhibits a 20-fold fluorescent enhancement when treated with ALDH1A1. Through the application of surface marker antibody staining, tumorsphere assays, and assessment of tumorigenicity, the disclosed results show that cells exhibiting high AlDeSense signal intensity have properties of cancer stem cells. Herein, is also reported the development of a red congener, red-AlDeSense. Importantly, red-AlDeSense represents one of only a few examples of a turn-on sensor in the red region using the d-PeT quenching mechanism.

Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

The direct, Pd-catalyzed ortho C-H methylation and fluorination of benzaldehydes have been accomplished using commercially available orthanilic acids as transient directing groups. In these reactions, the 1-fluoro-2,4,6-trimethylpyridinium salts can be either a bystanding F+ oxidant or an electrophilic fluorinating reagent. An X-ray crystal structure of a benzaldehyde ortho C-H palladation intermediate was obtained using triphenylphosphine as the stabilizing ligand.