- A New Method for Thiomethylation of Hydroxy-1,4-naphthoquinones with N -Acetyl- l -cysteine; First Synthesis of Fibrostatins B, C, and D
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A series of N-acetyl-S-[(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl]-l-cysteine conjugates were obtained in good yields by acid-catalyzed condensation of substituted 2-hydroxy-1,4-naphthoquinones with N-acetyl-l-cysteine and paraformaldehyde. Based on this reaction, a first synthesis of fibrostatins B, C, and D was developed.
- Sabutskii, Yuri E.,Polonik, Sergey G.,Denisenko, Vladimir A.,Dmitrenok, Pavel S.
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p. 2763 - 2770
(2015/02/19)
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