917885-01-9

Basic information

• Product Name: 5-Fluoro-6-hydroxyindan-1-one
• Synonyms: 5-Fluoro-6-hydroxyindan-1-one;5-Fluoro-6-hydroxy-2,3-dihydro-1H-inden-1-one
• CAS NO: 917885-01-9
• Molecular Formula: C9H7FO2
• Molecular Weight: 166.15
• Mol File: 917885-01-9.mol

Chemical Properties

• Boiling Point: 323.17°C at 760 mmHg
• Flash Point: 149.248°C
• Appearance: /
• Density: 1.412g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 5-Fluoro-6-hydroxyindan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-6-hydroxyindan-1-one(917885-01-9)
• EPA Substance Registry System: 5-Fluoro-6-hydroxyindan-1-one(917885-01-9)

Safety Data

• Hazardous Substances Data: 917885-01-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-6-hydroxyindan-1-one is used as a chemical intermediate in the synthesis of various drugs and pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Medicinal Chemistry Research:
5-Fluoro-6-hydroxyindan-1-one is used as a subject of study for its potential medicinal properties. Researchers are investigating its antioxidant and anti-inflammatory effects, which could lead to the development of new treatments for a variety of conditions.
Used in Neurodegenerative Disease Treatment:
5-Fluoro-6-hydroxyindan-1-one is being explored for its potential use in the development of therapeutic agents for the treatment of neurodegenerative diseases. Its unique characteristics may contribute to the creation of novel approaches to managing these complex conditions.

InChI:InChI=1/C9H7FO2/c10-7-3-5-1-2-8(11)6(5)4-9(7)12/h3-4,12H,1-2H2

Upstream product

• 351-54-2 3-fluoro-p-anisaldehyde 
• 69888-90-0 3-(3-fluoro-4-methoxyphenyl)propionic acid 
• 83802-71-5 5-fluoro-6-methoxy-2,3-dihydro-1H-inden-1-one 
• 2105-94-4 4-bromo-2-fluorophenol 
• 877064-69-2 methyl (E)-3-(3-fluoro-4-hydroxyphenyl)acrylate 
• 590417-24-6 3-(3-fluoro-4-hydroxyphenyl)propionic acid methyl ester 
• 69888-91-1 3-(3-fluoro-4-hydroxyphenyl)Propionic Acid 

Relevant articles and documents

8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)

Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT1A receptor and the serotonin transporter

The structure-activity relationship (SAR) for three series of lactam-fused chroman derivatives possessing 3-amino substituents was evaluated. Many compounds exhibited affinities for both the 5-HT1A receptor and the 5-HT transporter. Compounds 45 and 53 demonstrated 5-HT1A antagonist activities in the in vitro cAMP turnover model.

TRICYCLIC COMPOUNDS USEFUL AS SEROTONIN INHIBITORS AND 5-HT1A AGONISTS AND ANTAGONISTS

3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT1A receptor (agonizing or antagonizing) in a patient. These compounds are further useful for inhibiting binding to a serotonin receptor. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.