The present invention is directed to 3-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channel
-
Page/Page column 10-11
(2010/09/07)
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels
The discovery of a novel series of potent and selective T-type calcium channel antagonists is reported. Initial optimization of high-throughput screening leads afforded a 1,4-substituted piperidine amide 6 with good potency and limited selectivity over hE
Yang, Zhi-Qiang,Barrow, James C.,Snipe, William D.,Schlegel, Kelly-Ann S.,Shu, Youheng,Yang, F. Vivien,Lindsley, Craig W.,Rittle, Kenneth E.,Bock, Mark G.,Hartman, George D.,Uebele, Victor N.,Nuss, Cindy E.,Fox, Steve V.,Kraus, Richard L.,Doran, Scott M.,Connolly, Thomas M.,Tang, Cuyue,Ballard, Jeanine E.,Kuo, Yuhsin,Adarayan, Emily D.,Prueksaritanont, Thomayant,Zrada, Matthew M.,Marino, Michael J.,Graufelds, Valerie Kuzmick,DiLella, Anthony G.,Reynolds, Ian J.,Vargas, Hugo M.,Bunting, Patricia B.,Woltmann, Richard F.,Magee, Michael M.,Koblan, Kenneth S.,Renger, John J.
The present invention is directed to 3-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channel
-
Page/Page column 22; 23
(2008/06/13)
More Articles about upstream products of 918333-06-9