918538-04-2

Basic information

• Product Name: PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE
• Synonyms: PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE;Pyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione;pyrrolo[1,2-f][1,2,4]triazine-2,4(1H,3H)-dione;Pyrrolo[2,1-f][1,2,4]tria...;Pyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione (96%);PYRROLO[1,2-D][1,2,4]TRIAZINE-2,4(1H,3H)-DIONE;Pyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)
• CAS NO: 918538-04-2
• Molecular Formula: C6H5N3O2
• Molecular Weight: 151.1228
• Mol File: 918538-04-2.mol

Chemical Properties

• Appearance: /
• Density: 1.74±0.1 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.793
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.92±0.20(Predicted)
• CAS DataBase Reference: PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE(918538-04-2)
• EPA Substance Registry System: PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE(918538-04-2)

Safety Data

• Hazardous Substances Data: 918538-04-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE is used as a building block for the development of novel drugs. Its unique structure and reactivity allow for the creation of new pharmaceutical compounds with potential therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE serves as a versatile intermediate for the synthesis of various organic compounds. Its reactivity enables the formation of new chemical entities with potential applications in different industries.
Used in Material Science:
PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE is utilized as a component in the development of functional materials. Its unique structure contributes to the creation of materials with specific properties, such as catalytic activity or sensing capabilities.
Used in Research and Development:
PYRROLO[2,1-F][1,2,4]TRIAZINE-2,4-DIONE is employed as a target for research and development in the scientific community. Its potential biological activities and therapeutic properties make it an interesting subject for further exploration and innovation.

InChI:InChI=1/C6H5N3O2/c10-5-4-2-1-3-9(4)8-6(11)7-5/h1-3H,(H2,7,8,10,11)

Upstream product

• 1003-29-8 2-pyrrole aldehyde 
• 4513-94-4 1H-pyrrole-2-carbonitrile 
• 159326-66-6 N-amino-1H-pyrrole-2-carbonitrile 
• 159326-69-9 1-aminopyrrole-2-carboxamide 
• 541-41-3 chloroformic acid ethyl ester 
• 1379337-32-2 1-(ethoxyformamido)-1H-pyrrole-2-carboxamide 

Downstream Products

• 918538-08-6 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine 
• 1001353-82-7 2,4-dichloropyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde 
• 1001353-78-1 (S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-2-methylpyrrolidine-2-carboxylic acid 

Relevant articles and documents

Substituted heteroaryl compounds and compositions and uses thereof

The invention provides a substituted heteroaryl compound and a composition thereof, and applications of the compound and the composition. The compound is a compound as shown in a formula I, or stereoisomer, tautomer, oxynitride, solvate, metabolite, pharmaceutically-acceptable salt or prodrug of the compound as shown in the formula I. The invention also provides a pharmaceutical composition containing the above-mentioned compound; and the above-mentioned compound and the pharmaceutical composition are capable of adjusting the activity of JAK kinases and are applied in prevention, treatment, therapy and alleviation of JAK kinase mediated diseases or disorders.

MECHANISTIC TARGET OF RAPAMYCIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF

Selective mTOR inhibitors of formulas (I)-(III), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from abnormal cell growth, functions, or behaviors mediated by an mTOR kinase and/or one or more PI3K enzyme, are provided. Such diseases and disorder include cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

Heterocyclic amines Hedgehog signal pathway inhibitor

The invention relates to the field of biological medicine, in particular to a heterocyclic amine compound and an application thereof, namely a general formula (I) compound and acceptable salt in the pharmaceutical field. The compound can be used in the Hedgehog signal transduction inhibitor application and various medical applications (please see the formula in the specification). The invention further relates to a preparation method with the general formula (I).

Synthesis and medical application of pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound

The invention discloses a synthesis and medical application of pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound. The compound belongs to a novel-structure compound. The synthesis method is high in operating safety, mild in reaction condition and suitable for industrial production. The activity and the selectivity of BTK kinase and the in-vitro proliferation activity of a leukemia cell line are test, it is verified that the compound has the selective and irreversible inhibition effect on the BTK kinase, and has the different-degree inhibition effect on leukemia cells. According to measurement, the compound also has the good anti-arthritic activity on a collagen-induced arthritis (rCIA) model. The pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound can be used for preparing medicine for treating arthritis and leukemia.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a JAK-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of JAK-mediated disease.

Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors

A novel series of Hh signaling pathway inhibitors were designed by replacing the pyrimidine skeleton of our earlier reported lead compound 1 with pyrrolo[2,1-f][1,2,4]triazine scaffold. Starting from this new scaffold, SAR exploration was investigated based on structural modification on A-ring, C-ring and D-ring. And several much potent compounds were studies in vivo to profile their pharmacokinetic properties. Finally, optimization leads to the identification of compound 19a, a potent Hh signaling pathway inhibitor with superior potency in vitro and satisfactory pharmacokinetic properties in vivo.

PYRROLOTRIAZINE KINASE INHIBITORS

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