1379337-32-2

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(2-CarbaMoyl-pyrrol-1-yl)-carbaMic acid ethyl ester is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its carboxylic acid ester structure allows for further chemical reactions and modifications, making it a versatile building block in the development of new drugs.
Used in Organic Chemistry:
(2-CarbaMoyl-pyrrol-1-yl)-carbaMic acid ethyl ester is used as a building block for the synthesis of complex organic molecules. Its unique structure and functional groups enable it to participate in various organic reactions, contributing to the formation of diverse organic compounds with potential applications in various industries.
Further research and analysis would be needed to fully understand the potential uses and properties of (2-CarbaMoyl-pyrrol-1-yl)-carbaMic acid ethyl ester.

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 159326-69-9 1-aminopyrrole-2-carboxamide 
• 1003-29-8 2-pyrrole aldehyde 
• 159326-66-6 N-amino-1H-pyrrole-2-carbonitrile 
• 4513-94-4 1H-pyrrole-2-carbonitrile 

Downstream Products

• 918538-04-2 pyrrolo[2,1-f][1,2,4]triazine-2,4(1H, 3H)-dione 
• 1313036-56-4 2-chloro-4-(3-nitrophenoxy)pyrrolo[2,1-f][1,2,4]triazine 

Relevant academic research and scientific papers

2 - amino-pyrrolo [1, 2 - f] [1, 2, 4] triazine compounds, synthetic method and application

The invention discloses 2-aminopyrrolo[1,2-f][1,2,4]triazine compounds, and a synthesis method and application thereof, particularly 2-aminopyrrolo[1,2-f][1,2,4]triazine compounds, or pharmaceutically acceptable salts, hydrate, solvate or prodrug thereof.

Heterocyclic amines Hedgehog signal pathway inhibitor

The invention relates to the field of biological medicine, in particular to a heterocyclic amine compound and an application thereof, namely a general formula (I) compound and acceptable salt in the pharmaceutical field. The compound can be used in the Hedgehog signal transduction inhibitor application and various medical applications (please see the formula in the specification). The invention further relates to a preparation method with the general formula (I).

Synthesis and medical application of pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound

The invention discloses a synthesis and medical application of pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound. The compound belongs to a novel-structure compound. The synthesis method is high in operating safety, mild in reaction condition and suitable for industrial production. The activity and the selectivity of BTK kinase and the in-vitro proliferation activity of a leukemia cell line are test, it is verified that the compound has the selective and irreversible inhibition effect on the BTK kinase, and has the different-degree inhibition effect on leukemia cells. According to measurement, the compound also has the good anti-arthritic activity on a collagen-induced arthritis (rCIA) model. The pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound can be used for preparing medicine for treating arthritis and leukemia.

Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors

A novel series of Hh signaling pathway inhibitors were designed by replacing the pyrimidine skeleton of our earlier reported lead compound 1 with pyrrolo[2,1-f][1,2,4]triazine scaffold. Starting from this new scaffold, SAR exploration was investigated based on structural modification on A-ring, C-ring and D-ring. And several much potent compounds were studies in vivo to profile their pharmacokinetic properties. Finally, optimization leads to the identification of compound 19a, a potent Hh signaling pathway inhibitor with superior potency in vitro and satisfactory pharmacokinetic properties in vivo.

PYRROLOTRIAZINE KINASE INHIBITORS

The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.