- RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF
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A Rho-associated protein kinase (ROCK) inhibitor represented by formula (I), a pharmaceutical composition comprising same, and a use thereof for preventing or treating ROCK-mediated diseases.
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Paragraph 0125; 0158-0161; 0195-0198
(2022/01/12)
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- Preparation method for 5-bromoisoindoline hydrochloride
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The invention provides a preparation method for 5-bromoisoindoline hydrochloride. The method comprises the following steps: firstly esterifying 5-bromine-2-methyl benzoic acid, and then brominating methyl NBS, cyclizing and reducing with borane, thereby o
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Paragraph 0050; 0051; 0055; 0056; 0057; 0061-0063; 0067
(2018/04/02)
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- CHEMICAL COMPOUNDS
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The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
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