919346-89-7

Basic information

• Product Name: 5-BROMO-2,3-DIHYDRO-1H-ISOINDOLE HYDROCHLORIDE
• Synonyms: 5-BROMO-2,3-DIHYDRO-1H-ISOINDOLE HYDROCHLORIDE;5-Bromo-2,3-dihydro-1H-Isoindole HydrochlorideY;5-Bromo-isoindoline hydrochloride;1H-Isoindole, 5-broMo-2,3-dihydro-, hydrochloride (1:1);5-BroMoisoindoline hydrochloride (1:1);1H-Isoindole, 5-bromo-2,3-dihydro-, hydrochloride;5-Bromo-2,3-dihydro-1H-isoindole HCl;5-bromoisoindoline HCl salt
• CAS NO: 919346-89-7
• Molecular Formula: C₈H₈BrN*ClH
• Molecular Weight: 234.53
• Mol File: 919346-89-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 5-BROMO-2,3-DIHYDRO-1H-ISOINDOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,3-DIHYDRO-1H-ISOINDOLE HYDROCHLORIDE(919346-89-7)
• EPA Substance Registry System: 5-BROMO-2,3-DIHYDRO-1H-ISOINDOLE HYDROCHLORIDE(919346-89-7)

Safety Data

• Hazardous Substances Data: 919346-89-7(Hazardous Substances Data)

Usage

Uses

5-Bromoisoindoline Hydrochloride acts as a reagent in the preparation of cyanopyrrolidines as DUB inhibitors for the treatment of cancer, preparation of oxazolidinone containing fused ring as antibiotics, preparation of novel indolecarboxamides as IKK2 inhibitors. Also a derivative salt of 5-Bromoisoindoline Hydrochloride (B683270), which is an intermediate used in the synthesis of 2,3-dihydro-1H-isoindoles with high affinity and selectivity for dopamine D3 receptor.

InChI:InChI=1/C8H8BrN.ClH/c9-8-2-1-6-4-10-5-7(6)3-8;/h1-3,10H,4-5H2;1H

Upstream product

• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 24424-99-5 di-tert-butyl dicarbonate 
• 64990-51-8 hydrochloric acid 1,4-dioxane 
• 201940-08-1 5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 675109-26-9 6-bromo-1-oxo-2,3-dihydro-1H-isoindole 
• 79669-50-4 methyl 2-methyl-5-bromobenzoate 
• 79669-49-1 5-bromo-2-methylbenzoic acid 

Downstream Products

• 201940-08-1 5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 178445-27-7 benzyl 5-bromoisoindoline-2-carboxylate 
• 107834-37-7 5-bromo-2-methyl-2,3-dihydro-1H-isoindole 
• 127168-85-8 2-(p-toluenesulfonyl)-5-bromoisoindoline 
• 1428738-42-4 (R)-3-(3-fluoro-4-(2-(2-methyl-2H-tetrazol-5-yl) isoindolin-5-yl)phenyl)-5-(hydroxylmethyl)oxazolidin-2-one 

Relevant articles and documents

RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF

A Rho-associated protein kinase (ROCK) inhibitor represented by formula (I), a pharmaceutical composition comprising same, and a use thereof for preventing or treating ROCK-mediated diseases.

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.