- Nickel-Copper-Catalyzed Hydroacylation of Vinylarenes with Acyl Fluorides and Hydrosilanes
-
The hydroacylation of vinylarenes with acyl fluorides and hydrosilanes was enabled by a synergistic bimetallic Ni/Cu-catalytic system, giving access to the corresponding branched ketone products. The reaction takes place under mild conditions at 25–80 °C and tolerates base-sensitive functional groups such as methoxycarbonyl and acetoxy groups.
- Ueda, Yusuke,Iwai, Tomohiro,Sawamura, Masaya
-
supporting information
p. 9410 - 9414
(2019/05/29)
-
- Ylide-Functionalized Phosphine (YPhos)-Palladium Catalysts: Selective Monoarylation of Alkyl Ketones with Aryl Chlorides
-
Ylide-functionalized phosphine (YPhos) ligands allow the palladium-catalyzed α-arylation of alkyl ketones with aryl chlorides with record setting activity. Using a cyclohexyl-substituted YPhos ligand, a wide range of challenging ketone substrates was efficiently and selectively monoarylated under mild conditions. A newly designed YPhos ligand bearing tert-butyl groups on the coordinating phosphorus atom is already active at room temperature. The synthetic potential was demonstrated by gram-scale reactions and the succinct synthesis of ?-caprolactone derivatives.
- Hu, Xiao-Qiang,Lichte, Dominik,Rodstein, Ilja,Weber, Philip,Seitz, Ann-Katrin,Scherpf, Thorsten,Gessner, Viktoria H.,Goo?en, Lukas J.
-
supporting information
p. 7558 - 7562
(2019/10/02)
-
- Tautomer-selective derivatives of enolate, ketone and enaminone by addition reaction of picolyl-type anions with nitriles
-
We describe an efficient for the synthesis of compounds of tautomeric β-pyridyl/quinolyl-enol, -ketone, -enaminone, which were finally characterized by standard methods like NMR, IR or SCXRD. The addition reaction of lithiated intermediates of picoline, 2-ethylpyridine and 2-methylquinoline, respectively, with nitriles followed by acid hydrolysis afforded the corresponding tautomeric compounds of enol, ketone and emaminone. Interestingly, treatment of 2-methylpyridine or 2-ethylpyridine with nitriles, respectively, yielded mostly β-pyridyl ketone and enol tautomers without enaminones, while 2-methylquinoline with nitriles gave β-quinolyl ketone and enaminone tautomers without enols. The reaction of 2-benzylpyridine with nitriles was not available under the same conditions.
- Bai, Jianliang,Wang, Peng,Cao, Wei,Chen, Xia
-
p. 645 - 652
(2016/09/28)
-
- Di-tert-butylneopentylphosphine (DTBNpP): An Efficient Ligand in the Palladium-Catalyzed α-Arylation of Ketones
-
Di-tert-butylneopentylphosphine (DTBNpP) and palladium(II) acetate provide an efficient catalytic system for the α-arylation of ketones. Aryl bromides were coupled with ketones using 0.25-0.5 mol-% Pd(OAc)2/DTBNpP in toluene at 50 C, whereas aryl chlorides required a higher catalyst loading (0.5-2.0 mol-%) and a higher temperature (80 C). Coupling of 2-bromophenol with ketones using the Pd/DTBNpP system provides an efficient route for the synthesis of benzofurans.
- Raders, Steven M.,Jones, Jessica M.,Semmes, Jeffrey G.,Kelley, Steven P.,Rogers, Robin D.,Shaughnessy, Kevin H.
-
p. 7395 - 7404
(2016/02/19)
-
- ETHANAMINE COMPOUNDS AND THEIR USE FOR TREATING DEPRESSION
-
The present invention relates to ethanamine compounds, namely 1- (3-f luorophenyl) -2-methyl-2- (pyridine-2-yl) propan-1-amine and 2-methyl-l-phenyl-2- (pyridine-2yl) propan-1-amine, the enantiomers and salts thereof and their use for the treatment of depression.
- -
-
Page/Page column 23
(2010/07/09)
-
- A highly practical and general route for α-arylations of ketones using bis-phosphinoferrocene-based palladium catalysts
-
Well-defined, air-stable Pd complexes of bis-phosphinoferrocene family of catalysts have been studied in the arylation of various ketones with aryl chlorides and aryl bromides. Bis(di-tert-butyl)phosphinoferrocene (DtBPF)-based catalysts such as (DtBPF) P
- Grasa, Gabriela A.,Colacot, Thomas J.
-
p. 522 - 529
(2013/01/03)
-
- Formation and Decomposition of 1,2,3-Triazolines Prepared from Diphenyl Phosphorazidate (DPPA) and Enamines of Diaryl-Type Ketones
-
The pyrrolidine enamine 1 of deoxybenzoin reacted with diphenyl phosphorazidate (DPPA, (C6H5O)2P(O)N3) to give two amidines, the 1,2-migration product 7a and the 1,3-dipolar elimination product 8a in a ratio of 77:23.The reaction of DPPA with the enamine
- Kato, Nobuharu,Hamada, Yasumasa,Shioiri, Takayuki
-
p. 2496 - 2502
(2007/10/02)
-