92199-25-2

Upstream product

• 100-71-0 2-Ethylpyridine 
• 1620-53-7 1-phenyl-2-pyridin-2-ylethanone 
• 74-88-4 methyl iodide 
• 100-69-6 2-vinylpyridine 
• 455-32-3 benzoyl fluoride 
• 100-47-0 benzonitrile 
• 109-09-1 2-chloropyridine 
• 93-55-0 1-phenyl-propan-1-one 
• 109-04-6 2-bromo-pyridine 
• 1233072-63-3 1-phenyl-2-(pyridin-2-yl)-propan-1-ol 

Downstream Products

• 1233072-66-6 2-methyl-1-phenyl-2-(pyridin-2-yl)propan-1-one 
• 94191-46-5 Z-1-<1-phenyl-2-(2-pyridyl)-1-propenyl>pyrrolidine 
• 94191-43-2 E-1-<1-phenyl-2-(2-pyridyl)-1-propenyl>pyrrolidine 

Relevant academic research and scientific papers

Ylide-Functionalized Phosphine (YPhos)-Palladium Catalysts: Selective Monoarylation of Alkyl Ketones with Aryl Chlorides

Ylide-functionalized phosphine (YPhos) ligands allow the palladium-catalyzed α-arylation of alkyl ketones with aryl chlorides with record setting activity. Using a cyclohexyl-substituted YPhos ligand, a wide range of challenging ketone substrates was efficiently and selectively monoarylated under mild conditions. A newly designed YPhos ligand bearing tert-butyl groups on the coordinating phosphorus atom is already active at room temperature. The synthetic potential was demonstrated by gram-scale reactions and the succinct synthesis of ?-caprolactone derivatives.

Nickel-Copper-Catalyzed Hydroacylation of Vinylarenes with Acyl Fluorides and Hydrosilanes

The hydroacylation of vinylarenes with acyl fluorides and hydrosilanes was enabled by a synergistic bimetallic Ni/Cu-catalytic system, giving access to the corresponding branched ketone products. The reaction takes place under mild conditions at 25–80 °C and tolerates base-sensitive functional groups such as methoxycarbonyl and acetoxy groups.

Tautomer-selective derivatives of enolate, ketone and enaminone by addition reaction of picolyl-type anions with nitriles

We describe an efficient for the synthesis of compounds of tautomeric β-pyridyl/quinolyl-enol, -ketone, -enaminone, which were finally characterized by standard methods like NMR, IR or SCXRD. The addition reaction of lithiated intermediates of picoline, 2-ethylpyridine and 2-methylquinoline, respectively, with nitriles followed by acid hydrolysis afforded the corresponding tautomeric compounds of enol, ketone and emaminone. Interestingly, treatment of 2-methylpyridine or 2-ethylpyridine with nitriles, respectively, yielded mostly β-pyridyl ketone and enol tautomers without enaminones, while 2-methylquinoline with nitriles gave β-quinolyl ketone and enaminone tautomers without enols. The reaction of 2-benzylpyridine with nitriles was not available under the same conditions.

Di-tert-butylneopentylphosphine (DTBNpP): An Efficient Ligand in the Palladium-Catalyzed α-Arylation of Ketones

Di-tert-butylneopentylphosphine (DTBNpP) and palladium(II) acetate provide an efficient catalytic system for the α-arylation of ketones. Aryl bromides were coupled with ketones using 0.25-0.5 mol-% Pd(OAc)2/DTBNpP in toluene at 50 C, whereas aryl chlorides required a higher catalyst loading (0.5-2.0 mol-%) and a higher temperature (80 C). Coupling of 2-bromophenol with ketones using the Pd/DTBNpP system provides an efficient route for the synthesis of benzofurans.

ETHANAMINE COMPOUNDS AND THEIR USE FOR TREATING DEPRESSION

The present invention relates to ethanamine compounds, namely 1- (3-f luorophenyl) -2-methyl-2- (pyridine-2-yl) propan-1-amine and 2-methyl-l-phenyl-2- (pyridine-2yl) propan-1-amine, the enantiomers and salts thereof and their use for the treatment of depression.

A highly practical and general route for α-arylations of ketones using bis-phosphinoferrocene-based palladium catalysts

Well-defined, air-stable Pd complexes of bis-phosphinoferrocene family of catalysts have been studied in the arylation of various ketones with aryl chlorides and aryl bromides. Bis(di-tert-butyl)phosphinoferrocene (DtBPF)-based catalysts such as (DtBPF) P

Formation and Decomposition of 1,2,3-Triazolines Prepared from Diphenyl Phosphorazidate (DPPA) and Enamines of Diaryl-Type Ketones

The pyrrolidine enamine 1 of deoxybenzoin reacted with diphenyl phosphorazidate (DPPA, (C6H5O)2P(O)N3) to give two amidines, the 1,2-migration product 7a and the 1,3-dipolar elimination product 8a in a ratio of 77:23.The reaction of DPPA with the enamine