- COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS
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The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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Page/Page column 575
(2015/02/02)
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- Rhodium-catalyzed Reformatsky-type reaction of ethyl bromodifluoroacetate
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Treatment of a variety of carbonyl compounds with ethyl bromodifluoroacetate and Et2Zn in the presence of RhCl(PPh 3)3 in CH3CN afforded Reformatsky-type products in good to excellent yields in a mild reaction c
- Sato, Kazuyuki,Tarui, Atsushi,Kita, Tetsuya,Ishida, Yoshitaka,Tamura, Hanae,Omote, Masaaki,Ando, Akira,Kumadaki, Itsumaro
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p. 5735 - 5737
(2007/10/03)
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- Molar scale electrosynthesis of ethyl-2,2-difluoro-2-trimethylsilylacetate, a difluoromethylene building block precursor
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Ethyl-2,2-difluoro-2-trimethylsilylacetate has been prepared by electrolysis of ethyl-2-chloro-2,2-difluoroacetate in one step, at a molar scale, in the presence of a large excess of chlorotrimethylsilane. The transfer of the ethyl-2,2-difluoroacetate moiety to various electrophiles has been achieved. (C) 2000 Elsevier Science Ltd.
- Clavel, Philippe,Biran, Claude,Bordeau, Michel,Roques, Nicolas,Trévinc, Stéphane
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p. 8763 - 8767
(2007/10/03)
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- Synthesis of 1,1-difluoroalkenes via α,α-difluoro-β-lactones
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A new method for the general synthesis of 1,1-difluoroalkenes from ketones is presented.The procedure involves initial condensation of a ketone with the difluoro Reformatsky reagent, hydrolysis to form the α,α-difluoro-β-hydroxy acids, followed by cycliza
- Ocampo, Rogelio,Dolbier, William R.,Paredes, Rodrigo
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- Nucleophilic introduction of fluorinated alkyl groups into aldehydes and ketones using the corresponding alkyl halide with samarium(II) iodide
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Fluorinated alkyl groups such as PhCF2, C6F13, CF3CCl2 and CF2CO2Et are nucleophilically introduced into an aldehyde or ketone using fluorinated alkyl halides with SmI2/sub
- Yoshida, Masato,Suzuki, Daiki,Iyoda, Masahiko
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p. 643 - 648
(2007/10/03)
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- Practically useful Reformatsky type reactions of chlorodifluoroacetate and bromodifluoroacetate induced by samarium(II) diiodide
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Treatment of XCF2COOEt (X = Cl and Br) with SmI2 in THF gave efficiently β,β-difluorinated enolate equivalent, which was used for Reformatsky type reaction with aldehydes and ketones to give 2,2-difluoro-3-hydroxy ester.
- Yoshida, Masato,Suzuki, Daiki,Iyoda, Masahiko
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p. 2523 - 2529
(2007/10/03)
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- An effective synthesis of 2,2-difluoro-3-hydroxy esters
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Reformatsky reactions of bromodifluoroacetate with carbonyl compounds and its applications to the synthesis of 2,2-difluoro-3-hydroxy esters as a means of two-carbon homologation with a difluoro moiety under mild conditions in good to excellent yields are
- Shen, Yanchang,Qi, Ming
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p. 229 - 232
(2007/10/02)
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- 2,2-DIFLUORO-3-HYDROXYESTERS BY REFORMATSKII REACTION
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Ethyl bromodifluoroacetate undergoes facile Reformatskii addition to aldehydes and ketones to form 2,2-difluoro-3-hydroxyesters.
- Hallinan, E. Ann,Fried, Josef
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p. 2301 - 2302
(2007/10/02)
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