92207-61-9

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 108-94-1 cyclohexanone 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 

Relevant academic research and scientific papers

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Rhodium-catalyzed Reformatsky-type reaction of ethyl bromodifluoroacetate

Treatment of a variety of carbonyl compounds with ethyl bromodifluoroacetate and Et2Zn in the presence of RhCl(PPh 3)3 in CH3CN afforded Reformatsky-type products in good to excellent yields in a mild reaction c

Molar scale electrosynthesis of ethyl-2,2-difluoro-2-trimethylsilylacetate, a difluoromethylene building block precursor

Ethyl-2,2-difluoro-2-trimethylsilylacetate has been prepared by electrolysis of ethyl-2-chloro-2,2-difluoroacetate in one step, at a molar scale, in the presence of a large excess of chlorotrimethylsilane. The transfer of the ethyl-2,2-difluoroacetate moiety to various electrophiles has been achieved. (C) 2000 Elsevier Science Ltd.

Synthesis of 1,1-difluoroalkenes via α,α-difluoro-β-lactones

A new method for the general synthesis of 1,1-difluoroalkenes from ketones is presented.The procedure involves initial condensation of a ketone with the difluoro Reformatsky reagent, hydrolysis to form the α,α-difluoro-β-hydroxy acids, followed by cycliza

Nucleophilic introduction of fluorinated alkyl groups into aldehydes and ketones using the corresponding alkyl halide with samarium(II) iodide

Fluorinated alkyl groups such as PhCF2, C6F13, CF3CCl2 and CF2CO2Et are nucleophilically introduced into an aldehyde or ketone using fluorinated alkyl halides with SmI2/sub

Practically useful Reformatsky type reactions of chlorodifluoroacetate and bromodifluoroacetate induced by samarium(II) diiodide

Treatment of XCF2COOEt (X = Cl and Br) with SmI2 in THF gave efficiently β,β-difluorinated enolate equivalent, which was used for Reformatsky type reaction with aldehydes and ketones to give 2,2-difluoro-3-hydroxy ester.

An effective synthesis of 2,2-difluoro-3-hydroxy esters

Reformatsky reactions of bromodifluoroacetate with carbonyl compounds and its applications to the synthesis of 2,2-difluoro-3-hydroxy esters as a means of two-carbon homologation with a difluoro moiety under mild conditions in good to excellent yields are

2,2-DIFLUORO-3-HYDROXYESTERS BY REFORMATSKII REACTION

Ethyl bromodifluoroacetate undergoes facile Reformatskii addition to aldehydes and ketones to form 2,2-difluoro-3-hydroxyesters.