- 2,3,4-trihydroxybenzenesulfonamide derivatives as well as preparation method and application thereof
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The invention discloses 2,3,4-trihydroxybenzenesulfonamide derivatives as well as a preparation method and an application thereof. The specific structure is shown in formula (I). In the formula (I), most of 2,3,4-trihydroxybenzenesulfonamide derivatives s
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Paragraph 0018; 0026-0029
(2019/09/14)
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- Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins
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We report herein a new class of small-molecule inhibitors of antiapoptotic Bcl-2 proteins. The most potent compound, 7, binds to Bcl-2, Bcl-xL, and Mcl-1 proteins with Ki of 110, 638, and 150 nM, respectively. Compound 7 is highly effective in
- Tang, Guozhi,Yang, Chao-Yie,Nikolovska-Coleska, Zaneta,Guo, Jie,Qiu, Su,Wang, Renxiao,Gao, Wei,Wang, Guoping,Stuckey, Jeanne,Krajewski, Krzysztof,Jiang, Sheng,Roller, Peter P.,Wang, Shaomeng
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p. 1723 - 1726
(2007/10/03)
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- SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF
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The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
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Page/Page column 23
(2010/10/20)
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