573-11-5Relevant articles and documents
Total synthesis and RXRα-mediated transcription studies of neriifolone B and related compounds
Shen, Qirong,Dai, Yi,Wang, Guanghui,Yao, Fei,Duan, Yinghui,Chen, Haifeng,Zhang, Weige,Zhang, Xiaokun,Yao, Xinsheng
, p. 2671 - 2677 (2014/05/06)
Neriifolone B (1), a natural product containing a novel 4′,4′-dimethyl-4′,5′-dihydropyran-6-one[2′, 3′:3,4]xanthone skeleton, was found to be a potent inhibitor of transcription mediated by retinoid X receptor α (RXRα). The first total synthesis of neriifolone B (1) was achieved in 14 steps with an overall yield of 7.1%. A Claisen rearrangement was employed as the key step in the sequence. The activity of six natural xanthones and eight compounds related to neriifolone B (1) against RXRα-mediated transcription was evaluated. Two neriifolone B analogs, 17 and 11″, were potent inhibitors of RXRα transcriptional activity. Preliminary structure-activity relationship studies are discussed briefly.
NbCl5 mediated deprotection of methoxy methyl ether
Yadav,Ganganna,Bhunia, Dinesh C.,Srihari
experimental part, p. 4318 - 4320 (2009/10/26)
An efficient cleavage of methoxy methyl ether using NbCl5 is described. This protocol works efficiently with MOM ethers of alkyl, allyl, propargyl, benzyl alcohol and phenol derivatives. MOM esters are also found to be effectively cleaved under the present conditions.
CuCl catalyzed oxidation of aldehydes to carboxylic acids with aqueous tert-butyl hydroperoxide under mild conditions
Mannam, Sreedevi,Sekar
, p. 1083 - 1086 (2008/09/18)
Oxidation of aldehydes to the corresponding carboxylic acids can be performed highly efficiently at room temperature with 70% tert-butyl hydroperoxide (in water) in the presence of a catalytic amount of easily available ligand free CuCl in acetonitrile as solvent under very mild conditions. This oxidation protocol works well for various aldehydes including aliphatic aldehydes and aliphatic dialdehydes.
Efficient and rapid method for the oxidation of electron-rich aromatic aldehydes to carboxylic acids using improved basic hydrogen peroxide
Cong, Zhi-Qi,Wang, Chun-Ian,Chen, Tie,Yin, Bing-Zhu
, p. 679 - 683 (2007/10/03)
An efficient and rapid method for oxidation of electron-rich aromatic aldehydes to their corresponding carboxylic acids in excellent yields was developed. It is based on the oxidation of methoxy-substituted benzaldehydes in methanol with an improved aqueous basic hydrogen peroxide system. Benzaldehydes with electronwithdrawing substituents are oxidized to the corresponding carboxylic acid in excellent yields under mild reaction conditions. Copyright Taylor & Francis Group, LLC.
Synergistic compositions for the selective control of tumor tissue
-
, (2008/06/13)
According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.
Synergistically acting compositions for selectively combating tumor tissue
-
, (2008/06/13)
According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.
Manganese(III)-Mediated Formylation of Aromatic Compounds in the Presence of Malonic Acid
Nishino, Hiroshi,Tsunoda, Katsunori,Kurosawa, Kazu
, p. 545 - 550 (2007/10/02)
The reaction of naphthlenes with malonic acid in the presence of manganese(III) acetate gives naphthalenecarbaldehydes and naphthalenecarboxylic acids.Similar reactions of anthracene, pyrene, and methoxybenzenes also yield formylated and carboxylated products.It was found that the formyl group introduced to the aromatic ring was not derived from carboxymethyl radical generated directly by the thermolysis of manganese(III) acetate, but from a dicarboxymethyl radical formed by the interaction of malonic acid and manganese(III) acetate.In addition, it was also found that the dicarboxymethyl radicals attacked the position of the highest electron density on the aromatic ring and that this formylation was effective when the ionization potential of the aromatic copound was lower than 7.8 eV.
