- HERBICIDAL PYRIDAZINONE DERIVATIVES
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The present invention provides a compound of Formula (I) or an agronomically acceptable salt thereof, wherein: R2 is selected from the group consisting of (A1), (A2) and (A3) wherein X1 is N or CR7X2 is N or CR8X3 is N or CR9X4 is N or CR6R1, R3, R4, R5 R6, R7, R8 and R9 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.
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Page/Page column
(2014/09/29)
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- Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement
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Crystallographic structural information was used in the design and synthesis of a number of bioisosteric derivatives to replace the amide moiety in a lead series of p38a inhibitors which showed general hydrolytic instability in human liver preparations. Triazole derivative 13 was found to have moderate bioavailability in the rat and demonstrated potent in-vivo activity in an acute model of inflammation.
- Eastwood, Paul,González, Jacob,Gómez, Elena,Caturla, Francisco,Aguilar, Nuria,Mir, Marta,Aiguadé, Josep,Matassa, Victor,Balagué, Cristina,Orellana, Adelina,Domínguez, María
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scheme or table
p. 6253 - 6257
(2011/11/29)
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- New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
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This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.
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Page/Page column 37
(2009/12/04)
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- UNSATURATED HETEROCYCLIC DERIVATIVES
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This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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Page/Page column 40
(2008/06/13)
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