927819-90-7

Basic information

• Product Name: (R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE
• Synonyms: (R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE ;(R)-3-Benzyloxy Pyrrolidine Hcl;(3R)-3-(benzyloxy)pyrrolidine hydrochloride
• CAS NO: 927819-90-7
• Molecular Formula: C₁₁H₁₅NO*ClH
• Molecular Weight: 213.70384
• Mol File: 927819-90-7.mol

Chemical Properties

• Boiling Point: 304.7°C at 760 mmHg
• Flash Point: 138.1°C
• Appearance: /
• Vapor Pressure: 0.000639mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE(927819-90-7)
• EPA Substance Registry System: (R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE(927819-90-7)

Safety Data

• Hazardous Substances Data: 927819-90-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-3-Benzyloxy-pyrrolidine hydrochloride is used as a chiral building block for the synthesis of various drugs and biologically active molecules. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which is essential for the development of effective and safe pharmaceuticals.
Used in Organic Synthesis:
(R)-3-Benzyloxy-pyrrolidine hydrochloride is used as an intermediate in the synthesis of a wide range of organic compounds. Its versatility and reactivity make it a valuable component in the preparation of various chemical substances.
Used in Asymmetric Organic Reactions:
(R)-3-Benzyloxy-pyrrolidine hydrochloride is used as an effective catalyst in asymmetric organic reactions. Its ability to selectively promote the formation of one enantiomer over another is crucial in the synthesis of enantiomerically pure compounds, which are often required for biological activity and pharmaceutical applications.
Used in Catalyst Development:
(R)-3-Benzyloxy-pyrrolidine hydrochloride is used in the development of new catalysts for asymmetric reactions. Its unique properties and reactivity make it a promising candidate for the design of novel catalysts that can improve the efficiency and selectivity of various chemical processes.

InChI:InChI=1/C11H15NO.ClH/c1-2-4-10(5-3-1)9-13-11-6-7-12-8-11;/h1-5,11-12H,6-9H2;1H/t11-;/m1./s1

Upstream product

• 177947-67-0 (3R)-N-(tert-butyloxycarbonyl)-3-(benzyloxy)pyrrolidine 
• 177948-70-8 (3R)-N(H)-3-(benzyloxy)pyrrolidine 

Downstream Products

• 177948-70-8 (3R)-N(H)-3-(benzyloxy)pyrrolidine 

Relevant articles and documents

PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE

Provided are: a process for production of a benzyloxypyrrolidine derivative in high yield and safety, and a process for production of a hydrochloride powder of a benzyloxypyrrolidine derivative in high yield and safety; the process for production of a benzyloxypyrrolidine derivative expressed by the general formula (2) [Chemical formula 2], in reacting a pyrrolidinol derivative represented by the general formula (1) [Chemical formula 1 with a benzyl halide derivative in the presence of an alkali metal hydroxide, wherein the reaction is carried out in either of the following conditions A or B; condition A: an aprotic polar solvent, and condition B: an aliphatic ether solvent containing a phase transfer catalyst:

PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE

The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a N-protected-3-hydroxypyrrolidine is converted into a N-protected-3-aralkyloxypyrrolidine by allowing an aralkyl halide to act in the presence of a base and at least one of a metal halide and a phase-transfer catalyst followed by deprotecting a N-protecting group to convert it to a 3-aralkyloxypyrrolidine derivative and subsequently treating the derivative in a solvent containing a polar solvent, thereby obtaining the 3-aralkyloxypyrrolidine derivative as a crystal. According to the present invention, a 3-aralkyloxypyrrolidine derivative of high purity can be produced conveniently and efficiently on an industrial scale.