Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-β-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma
Cytotoxic nucleosides have proven to be ineffective for the treatment of hepatocellular carcinoma (HCC) due, in part, to their inadequate conversion to their active nucleoside triphosphates (NTP) in the liver tumor and high conversion in other tissues. Th
Boyer, Serge H.,Sun, Zhili,Jiang, Hongjian,Esterbrook, Julie,Gómez-Galeno, Jorge E.,Craigo, William,Reddy, K. Raja,Ugarkar, Bheemarao G.,MacKenna, Deidre A.,Erion, Mark D.
p. 7711 - 7720
(2007/10/03)
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