928780-22-7

Basic information

• Product Name: 4-amino-1-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[4-(4-chloro-phenyl)-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yloxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one
• Synonyms: 4-amino-1-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[4-(4-chloro-phenyl)-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yloxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one
• CAS NO: 928780-22-7
• Molecular Weight: 702.332
• Mol File: 928780-22-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-1-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[4-(4-chloro-phenyl)-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yloxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-1-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[4-(4-chloro-phenyl)-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yloxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one(928780-22-7)
• EPA Substance Registry System: 4-amino-1-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[4-(4-chloro-phenyl)-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yloxymethyl]-tetrahydro-furan-2-yl}-1H-pyrimidin-2-one(928780-22-7)

Safety Data

• Hazardous Substances Data: 928780-22-7(Hazardous Substances Data)

Upstream product

• 87418-91-5 1-[2',3'-di-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl]cytosine 
• 70200-14-5 ethyl 3-hydroxy-3-(4-chlorophenyl)propanoate 
• 104-88-1 4-chlorobenzaldehyde 
• 152467-43-1 1-(4-chlorophenyl)-1,3-propanediol 

Relevant articles and documents

Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-β-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma

Cytotoxic nucleosides have proven to be ineffective for the treatment of hepatocellular carcinoma (HCC) due, in part, to their inadequate conversion to their active nucleoside triphosphates (NTP) in the liver tumor and high conversion in other tissues. Th