92934-63-9

Basic information

• Product Name: (+)-Tropicamide
• Synonyms: Benzeneacetamide, N-ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (aR)- (9CI);Benzeneacetamide, N-ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (R)-
• CAS NO: 92934-63-9
• Molecular Weight: 0
• Mol File: 92934-63-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+)-Tropicamide(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-Tropicamide(92934-63-9)
• EPA Substance Registry System: (+)-Tropicamide(92934-63-9)

Safety Data

• Hazardous Substances Data: 92934-63-9(Hazardous Substances Data)

Usage

Uses

Used in Ophthalmology:
(+)-Tropicamide is used as a diagnostic and therapeutic agent for eye conditions, facilitating the examination and treatment process. It is particularly useful for:
1. Pupil Dilation: As a muscarinic acetylcholine receptor antagonist, (+)-Tropicamide is used to dilate the pupil, which is essential for comprehensive eye examinations and the diagnosis of various eye conditions.
2. Temporary Paralysis of the Ciliary Muscle: It is used to temporarily paralyze the ciliary muscle, which helps in the assessment of the eye's refractive state and the fitting of corrective lenses.
3. Examination and Treatment of Certain Eye Conditions: The dilation of the pupil and paralysis of the ciliary muscle provided by (+)-Tropicamide enable ophthalmologists to better examine the eye's interior, diagnose conditions, and administer appropriate treatments.
While (+)-Tropicamide is a valuable tool in ophthalmology, it can cause side effects such as blurred vision, increased sensitivity to light, and temporary stinging or discomfort in the eyes. Despite these potential side effects, its benefits in facilitating eye examinations and treatments make it an important medication in the field of ophthalmology.

Upstream product

• 14510-37-3 3-acetoxy-2-phenyl-propionyl chloride 
• 33403-97-3 4-(ETHYLAMINOMETHYL)PYRIDINE 
• 37504-67-9 α-[(acetyloxy)methyl]benzeneacetic acid 
• 54433-74-8 Ethyl-[1-pyridin-4-yl-meth-(E)-ylidene]-amine 
• 529-64-6 Tropic acid 
• 872-85-5 pyridine-4-carbaldehyde 
• 103-80-0 phenylacetyl chloride 
• 67-56-1 methanol 
• 33262-90-7 N-ethyl-2-phenyl-N-pyridin-4-ylmethyl-acetamide 
• 37504-67-9 (αS)-α-(acetoxymethyl)benzeneacetic acid 
• 1508-75-4 tropicamide 
• 17126-67-9 (+)-(R)-tropic acid 
• 177567-33-8 Acetic acid (R)-2-(ethyl-pyridin-4-ylmethyl-carbamoyl)-2-phenyl-ethyl ester 
• 183626-74-6 (αS)-α-(acetoxymethyl)benzeneacetyl chloride 

Relevant articles and documents

Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source

Herein, we report a cobalt-catalyzed α-hydroxymethylation of amides with methanol under mild conditions. Using CoCl2·6H2O as an inexpensive and efficient catalyst, some important bioactive β-hydroxyamides were obtained in moderate to excellent yields. The

Preparation method of topivacamide

The invention relates to a preparation method of topivacamide. The method comprises the following steps: (1) adding 3-hydroxy-2-phenylpropionic acid and toluene into a beaker, stirring uniformly, carrying out nitrogen displacement, protecting, and carrying out heating reflux until the mixture is insoluble; respectively adding triethylamine and acetyl chloride in the reaction, heating and refluxinguntil the solution is clear, cooling to room temperature, dropwise adding thionyl chloride, continuously reacting, and concentrating under reduced pressure to obtain 2-chlorocarbonyl-2-phenyl ethyl ester; and (2) preparing another jacketed bottle, adding ethylpyridine-4-ylmethylamine, triethylamine and methylbenzene, replacing with nitrogen, protecting, cooling, and slowly dropwise adding 2-chlorocarbonyl--2phenyl ethyl ester into the methylbenzene solution; after the dripping is finished, continuously reacting; (3) after the reaction is completed, dropwise adding water, carrying out liquid separation extraction, washing with saline water, adding a 3N hydrochloric acid solution into a toluene layer for hydrolysis, cooling to room temperature, carrying out liquid separation, separating toobtain a water phase, and washing with water phase ethyl acetate; (4) cooling, dropwise adding a saturated sodium bicarbonate aqueous solution to adjust the pH value, extracting with ethyl acetate, and concentrating an organic phase to obtain a faint yellow oily matter; and (5) dissolving the oily substance crude product with ethyl acetate, slowly dropwise adding heptane, crystallizing, carrying out suction filtration, and washing to obtain the target product topivacamide.

N-ethylpyridine methylamine mesylate crystal, preparation process thereof and application of N-ethylpyridine methylamine mesylate crystal in preparation of tropicamide

The invention discloses an N-ethylpyridine methylamine mesylate crystal, a preparation process thereof and the application of the N-ethylpyridine methylamine mesylate crystal in the preparation of tropicamide. Mesylate of N-ethylpyridine methylamine mesylate crystal is prepared from N-ethylpyridine methylamine and methylsulfonic acid, when X-ray powder diffraction is used, and the crystal has diffraction peaks at about 9.49 degrees, 13.16 degrees, 16.18 degrees, 19.10 degrees, 20.54 degrees, 23.24 degrees, 26.96 degrees and 34.63 degrees. The preparation method comprises the following steps ofdissolving the N-ethylpyridine methylamine in an organic solvent, and stirring at room temperature or heating and stirring until a material is completely dissolved; slowly adding acid, and crystallizing; and carrying out heat preservation aging, filtering and drying to obtain the tropicamide key starting material N-ethylpyridine methylamine mesylate crystal. The method is simple to operate and obvious in purification effect, the salt form impurity content and the crystal form impurity content prepared by crystallization are low, the purity is high, and the industrial production is facilitated.

Process for preparing N- ethylpyridine methylamine hydrochloride crystal, and application thereof in preparation of itemamide (by machine translation)

An application N - of,ethylpyridine methylamine hydrochloride crystal, prepared by dissolving N -ethylpyridine methylamine N - in an organic solvent, at room temperature or heating X - in an organic solvent is stirred until the material is completely dissolved, is stirred until the material is completely dissolved or stirred at about 9.73 °, 14.61 °, 17.98 °, 18.49 °, 20.36 °, 24.63 °, 27.21 ° with a diffraction peak, and is stirred. N - through a,ray powder diffractogram, for drying to obtain the supported product amide key starting material, ethyl-pyridine methylamine hydrochloride; is prepared by filtering, and drying. The crystal has the advantages of simple operation, purification effect, crystallization and high N -purity crystal, form impurity content in the, preparation of the itemamide hydrochloride, crystal . and is, simple and convenient, operation. (by machine translation)

N- Ethylpyridine methylamine hydrochloride and crystal, preparation process and application thereof

The invention discloses N -ethyl-pyridine methylamine trifluoroacetate, and a crystal. preparation process and application N - thereof to prepare N -ethylpyridine methylamine hydrochloride crystals, by slowly adding X -ethyl-pyridine methylamine, in an organic solvent 15.12 °, 15.45 °, 17.68 °, 20.68 °, 22.62 °, 23.25 °, 24.75 °, 29.54 ° at room temperature or heating. to fully dissolve N -ethyl-pyridine methylamine . through heating for, hours to prepare the ethyl-pyridine methylamine trifluoroacetate crystals . The method is simple in operation and;% in crystal form impurity content, obtained by dry-adding trifluoroacetic acid; crystals, at about, at room temperature or, in a heating mode of heating the crystals at a temperature ranging from, N - degrees, to a. material completely-dissolving solution.

Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC

The enantiomeric separation of eight anticholinergic drugs was first systematically examined on a derivative polysaccharide chiral stationary phase (CSP), i.e. Chiralpak ID in the normal phase mode. Except for scopolamine hydrobromide and benzhexol hydroc

Synthetic method of tropicamide

The invention relates to a production method of chemical medicines and particularly relates to a synthetic method of tropicamide. The synthetic method comprises the steps of carrying out hydrolysis and acylation on the raw material, namely diethyl phenylmalonate, condensing diethyl phenylmalonate with N-ethyl-4-methylpyridine amine, and generating reduction reaction with hydroboron, so as to obtain tropicamide. The synthetic method has the beneficial effects that the raw material cost is low, the properties of an intermediate product are stable, impurities are few, the operation steps such aspurification are reduced, and the process is simplified; reaction conditions are safe and mild, extremely toxic substances are not introduced, and the industrial amplified production is promoted; andby optimizing the raw material ratio, the total yield of the reaction is increased to be 65% and is greatly increased, and the production cost is lowered.

Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis

In the present study, hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) were used as additives in capillary electrophoresis for the enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine hydrochloride, isoprenaline hydrochloride, chlorpheniramine maleate, liarozole, tropicamide, amlodipine benzenesulfonate, brompheniramine maleate, and homatropine methylbromide. The effects of ionic liquid concentrations, salt effect, cations, and anions of ionic liquids on enantioseparation were investigated and the results proved that there was a synergistic effect between hydroxypropyl-β-cyclodextrin and the ionic liquid, and the cationic part of the ionic liquid played an important role in the increased resolution. With the developed dual system, all the enantiomers of 10 analytes were well separated in resolutions of 5.35, 1.76, 1.85, 2.48, 2.88, 1.43, 5.45, 4.35, 2.76, and 2.98, respectively. In addition, the proposed method was applied to the determination of the enantiomeric purity of S-ofloxacin after validation of the method in terms of selectivity, repeatability, linearity range, accuracy, precision, limit of detection (LOD), and limit of quality (LOQ). Chirality 25:409-414, 2013.

Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating non-inflammatory gastrointestinal tract disorders

A method is provided for using Cav2.2 subunit calcium channel modulators, particularly thiazolidinone, oxazolidinone, and imidazolone derivatives, to treat non-inflammatory gastrointestinal tract disorders.

Synthesis, characterization and pharmacological profile of tropicamide enantiomers

The synthesis, chemical characterization and antimuscarinic activity of the two enantiomers of tropicamide are reported. Functional (rabbit vas deferens, guinea pig heart (force) and ileum) as well as binding experiments (m1 and m4 human muscarinic receptors expressed in CHO-K1 cells; M2 and M3 receptors of rat heart and submaxillary gland membranes) were used to evaluate the antimuscarinic activity of the enantiomers. The results show that none of the enantiomers is able to significantly discriminate among the receptors studied and therefore do not support the proposal of tropicamide as an M4 (m4) selective agent.