930779-93-4Relevant articles and documents
Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate: Via aza-Michael-Michael addition
Chen, Chinpiao,Lee, Gene-Hsian,Palanimuthu, Arunan
, p. 13591 - 13600 (2020/04/23)
A three-component cascade reaction involving 2-alkenyl aniline, aldehydes, and ethyl cyanoacetate in the presence of DBU to synthesize highly substituted 1,2,3,4-tetrahydroquinolines is reported. The reaction proceeded through the Knoevenagel condensation
7-Methyl trimethoprim analogues as inhibitors of the folate metabolizing enzymes
Gangjee, Aleem,Lin, Xin,Queener, Sherry F.
, p. 507 - 512 (2007/10/03)
A series of 5-(1-phenylethyl)pyrimidines 2-10 (Table I) were designed and synthesized as potent and selective inhibitors of Pneumocystis carinii (P. carinii), Toxoplasma gondii (T. gondii) and Mycobacterium avium (M. avium) dihydrofolate reductases (DHFR)