88939-75-7

Basic information

• Product Name: 2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-
• Synonyms: Methyl (E)-3-(2-aminophenyl)-2-propenoate;Methyl trans-o-aminocinnamate;2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-
• CAS NO: 88939-75-7
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol File: 88939-75-7.mol
• Article Data: 73

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-(88939-75-7)
• EPA Substance Registry System: 2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-(88939-75-7)

Safety Data

• Hazardous Substances Data: 88939-75-7(Hazardous Substances Data)

Upstream product

• 39228-29-0 methyl 2-nitrocinnamate 
• 529-23-7 o-aminobenzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 615-43-0 2-iodophenylamine 
• 292638-85-8 acrylic acid methyl ester 
• 552-89-6 2-nitro-benzaldehyde 
• 5344-90-1 2-Aminobenzyl alcohol 
• 132993-22-7 2-nitrophenyl trifluoromethanesulfonate 
• 577-19-5 2-nitrophenyl bromide 
• 612-41-9 2-nitrocinnamic acid 
• 444-14-4 2-bromo-4,6-difluoroaniline 
• 39228-29-0 (E)-methyl 2-nitrocinnamate 
• 615-36-1 2-bromoaniline 
• 612-41-9 2-nitrocinnamic acid 

Downstream Products

• 231297-00-0 methyl trans-2-(phenylsulfonylamino)cinnamate 
• 659748-14-8 methyl 3-[2-(3-phenylureido)phenyl]acrylate 
• 741719-95-9 (E)-3-[2-(3-Cyclohexyl-ureido)-phenyl]-acrylic acid methyl ester 
• 912328-91-7 (E)-3-[2-(2-Trimethylsilanyl-ethoxycarbonylamino)-phenyl]-acrylic acid methyl ester 
• 912328-87-1 (E)-3-(2-Ethoxycarbonylamino-phenyl)-acrylic acid methyl ester 
• 839672-55-8 [2-(biphenyl-4-ylamino)-3-(5-tert-butoxycarbonylamino-pentyl)-3,4-dihydro-quinazolin-4-yl]-acetic acid 
• 839672-53-6 KYS₀₅₀₄₅ 
• 839672-58-1 KYS₀₅₀₄₈ 
• 839672-57-0 KYS₀₅₀₄₇ 
• 639478-88-9 3-(2-(nitroacetylamino)phenyl)propenonic acid methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects

As a bioisosteric strategy to overcome the poor metabolic stability of lead compound KYS05090S, a series of new fluoro-substituted 3,4-dihydroquinazoline derivatives was prepared and evaluated for T-type calcium channel (Cav3.2) block, cytotoxi

Enantioselective Rauhut–Currier Reaction with β-Substituted Acrylamides Catalyzed by N-Heterocyclic Carbenes

β-Substituted acrylamides have low electrophilicity and are yet to be exploited in the enantioselective Rauhut–Currier reaction. By exploiting electron-withdrawing protection of the amide and moderate nucleophilicity N-heterocyclic carbenes, such substrates have been converted to enantioenriched quinolones. The reaction proceeds with complete diastereoselectivity, good yield, and modest enantioselectivity. Derivatizations are reported, as are computational studies, supporting decreased amide bond character with electron-withdrawing protection of the nitrogen.

Synthesis of 2-(N-cyclicamino)quinoline combined with methyl (E)-3-(2/3/4-aminophenyl)acrylates as potential antiparasitic agents

A rationally designed series of 2-(N-cyclicamino)quinolines coupled with methyl (E)-3-(2/3/4-aminophenyl)acrylates was synthesized and subjected to in vitro screening bioassays for potential antiplasmodial and antitrypanosomal activities against a chloroquine-sensitive (3D7) strain of Plasmodium falciparum and nagana Trypanosoma brucei brucei 427, respectively. Substituent effects on activity were evaluated; meta-acrylate 24 and the ortho-acrylate 29 exhibited the highest antiplasmodial (IC50 = 1.4 μM) and antitrypanosomal (IC50 = 10.4 μM) activities, respectively. The activity against HeLa cells showed that the synthesized analogs are not cytotoxic at the maximum tested concentration. The ADME (absorption, distribution, metabolism, and excretion) drug-like properties of the synthesized compounds were predicted through the SwissADME software.