- Contrast agent and for the use of a synthetic composition, method and system (by machine translation)
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The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
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Paragraph 0551; 0564
(2016/10/07)
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- COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
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The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
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Paragraph 1366; 1387
(2015/07/22)
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- Functionalization of 4,5-Dichloropyridazin-3(2H)-one
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The functionalization of 4,5-dichloropyridazin-3(2H)-one and 4,5-dichloro-2-methyl-6-nitropyridazin-3(2H)-one was reported. A mixture of 4,5-dichloropyridazin-3(2H)-one, potassium nitrate and conc-sulfuric acid was stirred for 5 hours at 110-120°C. After cooling to room temperature, the solution was slowly poured into ice-water. The resulting yellow crystals was filtered, washed with water and dried in air to give the product. A mixture of 4,5-dichloro-6- nitropyridazin-3(2H)-one and POCl3 was refluxed for 24 hours. After cooling to room temperature, the solution was evaporated under reduced pressure. The resulting residue was slowly poured into ice-water (300 mL). Chlorination of compound 4,5-dichloro-6- nitropyridazin-3(2H)-one with phosphorus oxychloride also gave 3,4,5-trichloro-6-nitropyridazine in 72% yield. Three proton signals were also detected at d 9.0 (1H), 8.64 (1H) and 6.20 (2H) ppm in the spectrum of 1H NMR.
- Sung, Gi Hyeon,Kim, Bo Ram,Ryu, Ki Eun,Yoon, Yong-Jin
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p. 140 - 144
(2014/04/03)
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- HERBICIDAL PYRIDAZINONE DERIVATIVES
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The present invention provides a compound of Formula (I) or an agronomically acceptable salt thereof, wherein: R2 is selected from the group consisting of (A1), (A2) and (A3) wherein X1 is N or CR7X2 is N or CR8X3 is N or CR9X4 is N or CR6R1, R3, R4, R5 R6, R7, R8 and R9 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.
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Page/Page column
(2014/09/29)
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- HERBICIDAL PYRIDAZINONE DERIVATIVES
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The present invention provides a compound of Formula (I) or an agronomically acceptable salt thereof, wherein:R2 is selected from the group consisting of (A1), (A2) and (A3) wherein X1 is N or CR7 X2 is N or CR8 X3 is N or CR9 X4 is N or CR6 R1, R3, R4, R5 R6, R7, R8 and R9 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.
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Page/Page column 37
(2013/04/24)
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- DERIVATIVES OF 2H PYRIDAZIN- 3 -ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS
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The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: -R1 represents one or more groups such as: trif luoromethyl, halogen such as F, C1, -when n=m=1, W represents CH then Y represents oxygen, -U represents: ? either - (C=O) CH2NH- and is branched at position 4 of pyridazinone, then R2 represents H, ? or -(C=O)NH- and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, - R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enyzme inhibitors for the treatment of obesitz, tzpe-2 diabetes and lipid disorders.
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Page/Page column 46; 47
(2011/02/24)
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- SUBSTITUTED PYRIDAZINONE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS
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The present invention provides compounds according to Formulas I, II, III, IV, V, VI, VII or VIII; their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof
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Page/Page column 61-62
(2009/12/27)
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- Compounds for the Treatment of Neurodegeneration and Stroke
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Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.
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Page/Page column 13
(2008/06/13)
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- Concurrent Alkylation-Methoxylation of 4,5-Dihalopyridazin-6-ones and Synthesis of 5-Halo-4-hydroxypyridazin-6-ones
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1-Alkyl-5-halo-4-methoxypyridazin-6-ones were synthesized from 1-alkyl-4,5-dihalopyridazin-6-ones by the concurrent alkylation-methoxylation. 1-Alkyl-5-halo-4-hydroxypyridazin-6-ones were also prepared.
- Cho, Su-Dong,Choi, Woo-Yong,Yoon, Yong-Jin
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p. 1579 - 1582
(2007/10/03)
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- Retro-ene reaction. II. Reaction of 4,5-dichloro-1-hydroxymethylpyridazin-6-one with alkyl halides and carboxylic acid chlorides
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1-Alkyl-4,5-dichloropyridazin-6-ones and (4,5-dichloro-6-oxopyridazin-1-yl)methylcarboxylates were synthesized from 4,5-dichloro-1-hydroxymethylpyridazin-6-one and the corresponding alkyl halides or carboxylic acid chlorides. Also the reaction mechanisms via a fragmentation of retro-ene type are discussed.
- Kim, Sung-Kyu,Cho, Su-Dong,Kweon, Deok-Heon,Lee, Sang-Gyeong,Chung, Joo-Wha,Shin, Sung Chul,Yoon, Yong-Jin
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p. 245 - 248
(2007/10/03)
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- Studies on the Imidazopyridazine Ring System. Course of Alkylation of Imidazopyridazine-4-thione
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The syntheses of certain 4-(alkylthio)-, 4--, and 4-(arylthio)imidazopyridazines from imidazopyridazine-4-thione (1, 4-SIP) are described.When 1 equiv of alkylating agent is used, alkylation occurs, as expected, on sulfur; h
- Chen, Shih-Fong,Panzica, Raymond P.
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p. 2467 - 2473
(2007/10/02)
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