933-76-6

Basic information

• Product Name: 4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE
• Synonyms: 4,5-dichloro-2-methyl-3(2h)-pyridazinon;AKOS B029262;4,5-DICHLORO-2-METHYLPYRIDAZIN-3[2H]-ONE;4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE;4,5-DICHLORO-2-METHYLPYRIDAZINE-3(2H)-ONE;4,5-DICHLORO-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE;4,5-DICHLORO-2-METHYL-2H-PYRIDAZIN-3-ONE;4,5-DICHLORO-2-METHYL-3(2H)-PYRIDAZINONE
• CAS NO: 933-76-6
• Molecular Formula: C₅H₄Cl₂N₂O
• Molecular Weight: 179
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridazines
• Mol File: 933-76-6.mol

Chemical Properties

• Melting Point: 87-91 °C(lit.)
• Boiling Point: 197.2 °C at 760 mmHg
• Flash Point: 73.1 °C
• Appearance: Off-white to yellow low crystalline powder
• Density: 1.55 g/cm³
• Vapor Pressure: 0.382mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Ethanol
• PKA: -3.57±0.20(Predicted)
• CAS DataBase Reference: 4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE(933-76-6)
• EPA Substance Registry System: 4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE(933-76-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UR6188000
• Hazardous Substances Data: 933-76-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE is used as a key intermediate in the synthesis of 4-amino-3(2H)-pyridazinones and 5-amino-3(2H)-pyridazinones, which are important building blocks for the development of pharmaceutical compounds with potential therapeutic applications.
Used in Chemical Synthesis:
4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE is used as a starting material for the synthesis of various pyridazinone-based compounds, which can be further modified to create a wide range of chemical products with different properties and applications.
Used in Research and Development:
4,5-DICHLORO-2-METHYLPYRIDAZIN-3-ONE is utilized in research and development for the exploration of new chemical reactions and the discovery of novel pyridazinone-based compounds with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C5H4Cl2N2O/c1-9-5(10)4(7)3(6)2-8-9/h2H,1H3

Upstream product

• 766-40-5 Mucochloric acid 
• 302-15-8 methylhydrazine sulfuric acid 
• 87-56-9 mucochloric acid 
• 867130-68-5 4,5-dichloro-1-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid 
• 51355-97-6 4,5-dichloro-2-(hydroxymethyl)pyridazin-3(2H)-one 
• 74-88-4 methyl iodide 
• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 50500-59-9 2,6-dimethyl-2H-pyridazin-3-one 
• 867130-30-1 5-chloro-2,6-dimethyl-2H-pyridazin-3-one 
• 872826-22-7 4,5-dichloro-2,6-dimethyl-pyridazin-3-one 
• 60-34-4 methylhydrazine 

Downstream Products

• 98700-60-8 5-<(3-tert-Butyl-2-phenyl-1,3-oxazolidin-5-yl)methoxy>-4-chloro-2-methylpyridazin-3(2H)-one 
• 98700-64-2 4-<(3-tert-Butyl-2-phenyl-1,3-oxazolidin-5-yl)methoxy>-5-chloro-2-methylpyridazin-3(2H)-one 
• 40905-04-2 4-chloro-5-ethoxy-2-methyl-2H-pyridazin-3-one 
• 98795-98-3 5-Chloro-4-cyclohexylamino-2-methyl-2H-pyridazin-3-one 
• 98796-11-3 4-Chloro-5-cyclohexylamino-2-methyl-2H-pyridazin-3-one 
• 87633-88-3 3,7-dimethyl-10-benzyl-10H-dipyridazino<4,5-b:4',5'-e><1,4>thiazine-4,6(3H,7H)-dione 
• 87633-85-0 10-benzyl-2,7-dimethyl-10H-dipyridazino<4,5-b:4',5'-e><1,4>thiazine-1,6(2H,7H)-dione 
• 87633-91-8 2,6-dimethyl-9-benzyl-9H-dipyridazino<4,5-b:4',5'-d>pyrrole-1,5(2H,6H)-dione 
• 91364-79-3 5-(2-methyl-4-benzylamino-2,3-dihydro-3-oxo-pyridazinyl) 5'-(2'-methyl-4'-chloro-2',3'-dihydro-3'-oxo-pyridazinyl) sulfide 
• 96017-23-1 4-Chloro-2-methyl-5-(1-methylhydrazino)-3-(2H)-pyridazinone 
• 98796-09-9 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one 
• 98795-96-1 5-Chloro-2-methyl-4-methylaminopyridazin-3(2H)-one 
• 91736-88-8 4-(N-benzylamino)-5-chloro-2-methyl-3(2H)-pyridazinone 
• 148750-50-9 5-(N-benzylamino)-4-chloro-2-methyl-3(2H)-pyridazinone 

Relevant articles and documents

Contrast agent and for the use of a synthetic composition, method and system (by machine translation)

The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS

The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

Functionalization of 4,5-Dichloropyridazin-3(2H)-one

The functionalization of 4,5-dichloropyridazin-3(2H)-one and 4,5-dichloro-2-methyl-6-nitropyridazin-3(2H)-one was reported. A mixture of 4,5-dichloropyridazin-3(2H)-one, potassium nitrate and conc-sulfuric acid was stirred for 5 hours at 110-120°C. After cooling to room temperature, the solution was slowly poured into ice-water. The resulting yellow crystals was filtered, washed with water and dried in air to give the product. A mixture of 4,5-dichloro-6- nitropyridazin-3(2H)-one and POCl3 was refluxed for 24 hours. After cooling to room temperature, the solution was evaporated under reduced pressure. The resulting residue was slowly poured into ice-water (300 mL). Chlorination of compound 4,5-dichloro-6- nitropyridazin-3(2H)-one with phosphorus oxychloride also gave 3,4,5-trichloro-6-nitropyridazine in 72% yield. Three proton signals were also detected at d 9.0 (1H), 8.64 (1H) and 6.20 (2H) ppm in the spectrum of 1H NMR.

HERBICIDAL PYRIDAZINONE DERIVATIVES

The present invention provides a compound of Formula (I) or an agronomically acceptable salt thereof, wherein: R2 is selected from the group consisting of (A1), (A2) and (A3) wherein X1 is N or CR7X2 is N or CR8X3 is N or CR9X4 is N or CR6R1, R3, R4, R5 R6, R7, R8 and R9 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.

HERBICIDAL PYRIDAZINONE DERIVATIVES

The present invention provides a compound of Formula (I) or an agronomically acceptable salt thereof, wherein:R2 is selected from the group consisting of (A1), (A2) and (A3) wherein X1 is N or CR7 X2 is N or CR8 X3 is N or CR9 X4 is N or CR6 R1, R3, R4, R5 R6, R7, R8 and R9 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.

DERIVATIVES OF 2H PYRIDAZIN- 3 -ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS

The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: -R1 represents one or more groups such as: trif luoromethyl, halogen such as F, C1, -when n=m=1, W represents CH then Y represents oxygen, -U represents: ? either - (C=O) CH2NH- and is branched at position 4 of pyridazinone, then R2 represents H, ? or -(C=O)NH- and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, - R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enyzme inhibitors for the treatment of obesitz, tzpe-2 diabetes and lipid disorders.

SUBSTITUTED PYRIDAZINONE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS

The present invention provides compounds according to Formulas I, II, III, IV, V, VI, VII or VIII; their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof

Compounds for the Treatment of Neurodegeneration and Stroke

Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.

Retro-ene reaction. II. Reaction of 4,5-dichloro-1-hydroxymethylpyridazin-6-one with alkyl halides and carboxylic acid chlorides

1-Alkyl-4,5-dichloropyridazin-6-ones and (4,5-dichloro-6-oxopyridazin-1-yl)methylcarboxylates were synthesized from 4,5-dichloro-1-hydroxymethylpyridazin-6-one and the corresponding alkyl halides or carboxylic acid chlorides. Also the reaction mechanisms via a fragmentation of retro-ene type are discussed.

Concurrent Alkylation-Methoxylation of 4,5-Dihalopyridazin-6-ones and Synthesis of 5-Halo-4-hydroxypyridazin-6-ones

1-Alkyl-5-halo-4-methoxypyridazin-6-ones were synthesized from 1-alkyl-4,5-dihalopyridazin-6-ones by the concurrent alkylation-methoxylation. 1-Alkyl-5-halo-4-hydroxypyridazin-6-ones were also prepared.