932-22-9

Basic information

• Product Name: 4,5-Dichloro-3(2H)-pyridazinone
• Synonyms: AURORA KA-447;LABOTEST-BB LT00138189;AKOS B029197;4,5-DICHLOROPYRIDAZIN-3(2H)-ONE;4,5-DICHLOROPYRIDAZIN-3-ONE;4,5-Dichloro-3-pyridazinol;4,5-DICHLORO-3-HYDROXYPYRIDAZINE;4,5-DICHLORO-3(2H)-PYRIDAZINONE
• CAS NO: 932-22-9
• Molecular Formula: C₄H₂Cl₂N₂O
• Molecular Weight: 164.98
• Product Categories: Pyridazine series;Piperazine series;Bases & Related Reagents;Heterocycles;Nucleotides
• Mol File: 932-22-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 204-206 °C(lit.)
• Boiling Point: 339.2 °C at 760 mmHg
• Flash Point: 159 °C
• Appearance: White to yellow/Crystalline Powder
• Density: 1.76 g/cm³
• Vapor Pressure: 2.46E-06mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 8.39±0.60(Predicted)
• BRN: 120959
• CAS DataBase Reference: 4,5-Dichloro-3(2H)-pyridazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dichloro-3(2H)-pyridazinone(932-22-9)
• EPA Substance Registry System: 4,5-Dichloro-3(2H)-pyridazinone(932-22-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• RTECS: UR6182000
• HazardClass: IRRITANT
• Hazardous Substances Data: 932-22-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 932-22-9 differently. You can refer to the following data:
1. A new labelled substituted pyridazinone with tuberculostatic action
2. A new labelled substituted pyridazinone with tuberculostatic action.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 28, p. 385, 1991 DOI: 10.1002/jhet.5570280234

General Description

The solid phase FT-IR and FT-Raman spectra of 4,5-dichloro-3-hydroxypyridazine was studied.

InChI:InChI=1/C4H2Cl2N2O/c5-2-1-7-4(9)8-3(2)6/h1H,(H,7,8,9)

Upstream product

• 87-56-9 mucochloric acid 
• 51355-97-6 4,5-dichloro-2-(hydroxymethyl)pyridazin-3(2H)-one 
• 123-30-8 4-amino-phenol 
• 859214-48-5 2-cyano-4,5-dichloropyridazin-3(2H)-one 
• 108-91-8 cyclohexylamine 
• 100-46-9 benzylamine 
• 131242-36-9 2-sulfanylpyrimidine 
• 766-40-5 Mucochloric acid 
• 110-87-2 3,4-dihydro-2H-pyran 
• 89089-14-5 2,4,5-trichloropyridazin-3(2H)-one 
• 57697-64-0 mucochloric acid 
• 134541-32-5 4,5-Dichloro-2-(1,1-dibromo-2-oxo-propyl)-2H-pyridazin-3-one 
• 14161-11-6 3,4,5-trichloropyridazine 
• 1122-17-4 dichloromaleic acid anhydride 

Downstream Products

• 504-30-3 2H-Pyridazin-3-one 
• 55271-58-4 4-amino-5-chloro-2H-pyridazin-3-one 
• 6339-19-1 5-amino-4-chloropyridazin-3(2H)-one 
• 14161-11-6 3,4,5-trichloropyridazine 
• 100563-02-8 4,5-dichloro-2-(2-morpholinoethyl)pyridazin-3(2H)-one 
• 62688-74-8 10-acetyl-8-nitro-3H,10H-benzo[b]pyridazino[4,5-e][1,4]thiazin-4-one 
• 55271-55-1 3H,10H-dipyridazino[4,5-b;4',5'-e][1,4]thiazin-4-one 
• 13617-04-4 2H,7H-[1,4]dithiino[2,3-d;5,6-d']dipyridazine-1,6-dione 
• 153276-34-7 4-chloro-5-(piperazin-1-yl)-2,3-dihydropyridazin-3-one 
• 82412-97-3 4-chloro-5-<(2-hydroxyethyl)methylamino>-3(2H)-pyridazinone 
• 51659-49-5 1-Butyl-4,5-dichlor-pyridazon 
• 85302-02-9 1-oxo-1,2-dihydro-2,3-diazaphenoxathiin 
• 85302-01-8 4-oxo-3,4-dihydro-2,3-diazaphenoxathiin 
• 92574-75-9 2-((benzyloxy)methyl)-4,5-dichloropyridazin-3(2H)-one 

Relevant articles and documents

One-Pot Highly Regioselective Synthesis of Indole-Fused Pyridazino[4,5- b ][1,4]benzoxazepin-4(3 H)-ones by a Smiles Rearrangement

A simple and convenient synthesis of indole-fused pyridazino[4,5- b ][1,4]benzoxazepin-4(3 H)-ones is described. A range of 2-(1 H -indol-2-yl)phenols and 4,5-dichloropyridazin-3-ones are compatible with this reaction. A Smiles rearrangement is proposed as a key step in the highly regioselective construction of the products. The easy availability of the starting materials makes this an appealing method in organic synthesis.

A oxadiazole compound and its preparation method

The present invention relates to an oxadiazole compound and a preparation method thereof, wherein the molecular formula of the compound is as the follow, R1 is halogen, hydrogen, C1-C4 alkyl or alkoxy, R2 is halogen, hydrogen or alkyl, and R3 is methylamine, dimethylamine, isopropylamine, propylamine, butylamine, morpholine, piperidine or imidazole. Compared with the oxadiazole compound and the preparation method in the prior art, the oxadiazole compound and the preparation method of the present invention have the following characteristics that: the process is simple, the application range is wide, and the oxadiazole compound is suitable for prevention and control of health pests such as flies, mosquitoes, fleas and the like and agricultural pests such as lissorhoptrus oryzophilus, spodoptera exigua hiibner, mythimna separata (walker) and the like, can be provided for inhibiting growth of insects, especially mosquito larvae, and is an insecticide with an application prospect.

Access to 4-alkylaminopyridazine derivatives via nitrogen-assisted regioselective pd-catalyzed reactions

3-Substituted, 6-substituted, and unsymmetrical 3,6-disubstituted 4-alkylaminopyridazines were prepared from a sequence of three chemo- and regioselective reactions combining amination and palladium-catalyzed cross-coupling reactions, such as reductive dehalogenation and Suzuki-Miyaura reactions. Extension of the methodology to Sonogashira reaction yielded a novel class of 3-substituted pyrrolopyridazines.