933746-73-7 Usage
Uses
Used in Pharmaceutical Industry:
2-(2-Methoxyethyl)pyrrolidine is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and functional groups allow it to be incorporated into the molecular frameworks of different drugs, enhancing their therapeutic properties and efficacy.
Used in Agrochemical Industry:
2-(2-Methoxyethyl)pyrrolidine is also utilized as a key intermediate in the development of agrochemicals. Its ability to participate in various chemical reactions enables the creation of compounds with pesticidal, herbicidal, or other agricultural applications, contributing to the improvement of crop protection and yield.
Used in Organic Synthesis:
As a versatile intermediate, 2-(2-Methoxyethyl)pyrrolidine is used in organic synthesis for a wide range of applications. Its reactivity and compatibility with different chemical processes make it a valuable component in the preparation of complex organic molecules, including those with potential applications in materials science, specialty chemicals, and other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 933746-73-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,3,7,4 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 933746-73:
(8*9)+(7*3)+(6*3)+(5*7)+(4*4)+(3*6)+(2*7)+(1*3)=197
197 % 10 = 7
So 933746-73-7 is a valid CAS Registry Number.
933746-73-7Relevant articles and documents
Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents
Limpachayaporn, Panupun,Sch?fers, Michael,Schober, Otmar,Kopka, Klaus,Haufe, Günter
, p. 2025 - 2036 (2013)
Downstream caspases-3 and -7 are essential to execute the programmed type I cell death (apoptosis). In order to better understand their role, specific inhibitors of these enzymes are required, which after radiolabeling can be applied to non-invasively visualize and monitor apoptotic pathways in vivo using Positron Emission Tomography (PET). Therefore, 2-methoxyethyl-, 2-methoxypropyl-, 2-ethoxymethyl-, 2-(2-fluoroethoxymethyl)-, and 2-(2,2,2-trifluoroethoxymethyl)pyrrolidinyl analogues of (S)-5-[1-(2- methoxymethylpyrrolidinyl)sulfonyl]isatin (2) were prepared and their in vitro binding affinities towards caspases-1, -3, -6 and -7 were evaluated and compared to that of the lead structure 2. While the inhibition potencies against caspases-1 and -6 were in the micromolar range, all synthesized compounds exhibited excellent and selective inhibition of caspases-3 and -7 in the nanomolar range up to IC50 = 4.79 nM and 7.47 nM, respectively. These highly potent 2-substituted analogues of 2 might be developed as anti-apoptosis agents and some selected fluorinated inhibitors might be useful as potential PET radiotracers for apoptosis imaging after 18F-labeling.
