- Synthetic method of 6-hydrazino-1H-pyrazolo[3,4-b]pyridine and downstream product thereof
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The invention discloses a synthetic method of 6-hydrazino-1H-pyrazolo[3,4-b]pyridine and a downstream product thereof, and relates to the technical field of the organic chemical industry intermediatesynthesis. The synthetic method of the 6-hydrazino-1H-pyrazolo[3,4-b]pyridine comprises the following steps: firstly using easily obtained 2,6-dichloro-3-pyridylaldehyde and hydrazine hydrate as raw materials, to obtain the 6-hydrazino-1H-pyrazolo[3,4-b]pyridine, and using the 6-hydrazino-1H-pyrazolo[3,4-b]pyridine to synthesize the downstream product of 6-bromo-1H-pyrazolo[3,4-b]pyridine thereof.The synthetic method is capable of solving problems of preparing the 6-bromo-1H-pyrazolo[3,4-b]pyridine in the prior art that the raw materials are expensive and the yield is low. The route is mild in reaction condition, simple in follow-up operation, and environmentally friendly. A product is prepared in the higher yield and high purity, and the method is suitable for industrialized technology amplification.
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Page/Page column 6-8
(2018/12/05)
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- HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES
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Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.
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Paragraph 000596
(2016/05/02)
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