934826-68-3

Basic information

• Product Name: SKQ1 Bromide
• Synonyms: SKQ1 Bromide;(10-(4,5-Dimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl)triphenylphosphonium bromide;Visomitin
• CAS NO: 934826-68-3
• Molecular Formula: C36H42BrO2P
• Molecular Weight: 617.62
• EINECS: 604-604-1
• Mol File: 934826-68-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: SKQ1 Bromide(CAS DataBase Reference)
• NIST Chemistry Reference: SKQ1 Bromide(934826-68-3)
• EPA Substance Registry System: SKQ1 Bromide(934826-68-3)

Safety Data

• Hazardous Substances Data: 934826-68-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
SKQ1 Bromide is used as a neuroprotective agent for preventing neuronal loss and synaptic damage in Alzheimer’s disease. Its ability to mitigate the severity of arthritic lesions in rats makes it a potential candidate for the treatment of arthritis.
Used in Ophthalmology:
SKQ1 Bromide is used as an age-related ocular pathologies treatment, as it slows the development of such conditions in murine, porcine, bovine, and canine model systems.
Used in Cardiovascular Medicine:
SKQ1 Bromide is used as a preventative measure against acute phenoptosis following conditions like rhabdomyolysis, stroke, and myocardial infarction, thereby offering protection to the heart and other affected tissues.
Used in Anti-Aging Applications:
As a mitochondria-targeted antioxidant, SKQ1 Bromide is used to delay some manifestations of aging, similar to the effects of Visomitin, another mitochondria-targeted antioxidant.

Upstream product

• 526-75-0 2,3-Dimethylphenol 
• 2834-05-1 11-bromoundecanoic acid 
• 603-35-0 triphenylphosphine 
• 526-86-3 2,3-dimethyl-1,4-benzoquinone 
• 7530-96-3 (11-carboxyundecyl)triphenylphosphonium bromide 
• 608-43-5 2,3-dimethyl-1,4-dihydroxybenzene 
• 128209-65-4 2,3-dimethyl-5-(10'-bromodecyl)-1,4-benzoquinone 

Relevant articles and documents

BIOLOGICALLY ACTIVE COMPOUNDS SPECIFICALLY DELIVERED INTO MITOCHONDRIA

This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical potential in the mitochondria. This invention also relates to the method to affect an organism by the targeted delivery of biologically active compounds to mitochondria. The invention can be useful in treatment of diseases or disorders associated with not normal functioning of mitochondria, in particular diseases associated with increased production of free radicals and reactive oxygen species.

PHARMACEUTICAL SUBSTANCES ON THE BASIS OF MITOCHONDRIALLY ADDRESSED ANTIOXIDANTS

This invention relates to the fields of pharmaceutics and medicine, and, in particular, relates to the production and use of pharmaceutical substances on the basis of mitochondria-addressed compounds. The invention discloses methods for synthesis, purification and storage of mitochondria-addressed antioxidants, making it possible to produce said substances in a form and quality meeting the demands made on active ingredients of medicinal preparations - the pharmaceutical substances. The invention also discloses methods for design and selection of new mitochondria-addressed antioxidants having specified properties.

PHARMACEUTICAL SUBSTANCES ON THE BASIS OF MITOCHONDRIA-ADDRESSED ANTIOXIDANTS

This invention relates to the fields of pharmaceutics and medicine, and, in particular, relates to the production and use of pharmaceutical substances on the basis of mitochondria-addressed compounds. The invention discloses methods for synthesis, purification and storage of mitochondria-addressed antioxidants, making it possible to produce said substances in a form and quality meeting the demands made on active ingredients of medicinal preparations—the pharmaceutical substances. The invention also discloses methods for design and selection of new mitochondria-addressed antioxidants having specified properties.

METHOD OF ACTING UPON ORGANISM BY TARGETED DELIVERY OF BIOLOGICALY ACTIVE SUBSTANCES INTO M ITOCHONDRIA, PHARMACEUTICAL COMPOSITION FOR CARRYING OUT SAID METHOD, AND COMPOUND USED FOR THE PURPOSE

This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical potential in the mitochondria. This invention also relates to the method to affect an organism by the targeted delivery of biologically active compounds to mitochondria. The invention can be useful in treatment of diseases or disorders associated with not normal functioning of mitochondria, in particular diseases associated with increased production of free radicals and reactive oxygen species.