935668-00-1

Basic information

• Product Name: 3-ETHYL-3-AZETIDINOL HYDROCHLORIDE
• Synonyms: 3-ETHYL-3-AZETIDINOL HYDROCHLORIDE;3-ethylazetidin-3-ol hydrochloride;3-Ethyl-3-hydroxyazetidin...;3-Ethyl-3-hydroxyazetidine hydrochloride;3-Ethyl-3-azetidinol HCl;3-ETHYL-3-HYDROXY-AZETIDINE HCL;3-ethylazetidin-3-ol hydrochoride
• CAS NO: 935668-00-1
• Molecular Formula: C5H11NO.ClH
• Molecular Weight: 137.609
• Mol File: 935668-00-1.mol

Chemical Properties

• Boiling Point: 218.3°C at 760 mmHg
• Flash Point: 85.8°C
• Appearance: /
• Vapor Pressure: 0.027mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-ETHYL-3-AZETIDINOL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ETHYL-3-AZETIDINOL HYDROCHLORIDE(935668-00-1)
• EPA Substance Registry System: 3-ETHYL-3-AZETIDINOL HYDROCHLORIDE(935668-00-1)

Safety Data

• Hazardous Substances Data: 935668-00-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Ethyl-3-azetidinol hydrochloride is used as a sedative and anxiolytic agent for the treatment of anxiety and tension. It is administered orally or intravenously to promote the release of the neurotransmitter GABA, which has a calming effect on the central nervous system.
Used in Research:
3-Ethyl-3-azetidinol hydrochloride is used as a chemical reagent in the synthesis of other compounds, contributing to the development of new pharmaceutical agents and chemical compounds.

InChI:InChI=1/C5H11NO.ClH/c1-2-5(7)3-6-4-5;/h6-7H,2-4H2,1H3;1H

Upstream product

• 147293-65-0 1-(diphenylmethyl)-3-ethyl-3-azetidinol 

Relevant articles and documents

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical properties, pharmacokinetic profile, in vivo efficacy, and safety profile. This optimization effort discovered 46, which met our target candidate profile. Compound 46 had excellent activity against cultured Plasmodium falciparum, and in vivo against P. falciparum and P. berghei in infected mice. It exhibited good PK properties in mice, rats, and dogs. It was highly active against the other 11 P. falciparum strains, which are mostly resistant to chloroquine and pyrimethamine. The rapid parasite in vitro reduction and in vivo parasite clearance profile of 46 were similar to those of artemisinin and chloroquine, two rapid-acting antimalarials. It was nongenotoxic in an Ames assay, an in vitro micronucleus assay, and an in vivo rat micronucleus assay when dosed orally up to 2000 mg/kg. The combined properties of this novel benzoxaborole support its progression to preclinical development.

TAXANE COMPOUND WITH AZETIDINE RING STRUCTURE

A compound represented by the general formula (1) [X1 and X2 represent hydrogen atom, a halogen atom, hydroxyl group and the like, R1 represents a phenyl group, R2 represents an alkyl group, an alkenyl group, or