- O-SUBSTITUTED ANILINE DERIVATIVE AND ANTIOXIDANT DRUG
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A compound or a salt thereof that exhibits effective antioxidant activity in the treatment of ischemic organ disorders such as arteriosclerosis, myocardial infarction and brain infarction, in the treatment of diseases caused by oxidative cell damage such as renal disease, and in the inhibition of retinal lesions caused by oxidation due to the effects of light or the like. Also provided is an antioxidant drug containing at least one of the compounds or salts as an active ingredient. A compound represented by a formula (1) or a salt thereof, and an antioxidant drug containing at least one of the compound and the salt as an active ingredient. {In the formula (1): a represents either 1 or 2, R0 represents an unsubstituted or substituted amino group, R1 to R4 each represent, independently, a hydrogen atom or an alkyl group, E represents an unsubstituted or substituted alkylene chain, D represents a single bond, oxygen atom, unsubstituted or substituted nitrogen atom, sulfur atom, sulfinyl group, sulfonyl group, carbonyl group, carbonylamino group or aminocarbonyl group, and A represents an unsubstituted or substituted aromatic hydrocarbon group, unsubstituted or substituted heterocyclic group, unsubstituted or substituted aralkyl group, or unsubstituted or substituted heteroaralkyl group.}
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(2008/12/06)
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