- EXO-AZA SPIRO INHIBITORS OF MENIN-MLL INTERACTION
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Provided are compounds of Formula (I), pharmaceutical compositions comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes.
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- Phenylalaninamide pesticides and a preparing method thereof
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The invention relates to the technical fields of organic synthesis and application techniques, and particularly relates to phenylalaninamide pesticides and a preparing method thereof. Phenylalanine, substituted phenylacetic acid, and the like are adopted
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- Phenylazole compounds, process for producing the same and drugs for hyperlipemia
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Phenylazole compounds represented by general formula (1) or pharmaceutically acceptable salts thereof and drugs for hyperlipemia which contain these compounds as the active ingredient, wherein A represents imidazolyl, pyrazolyl, etc.; B represents (1a) or (1b) (wherein R2and R3represent each hydrogen, C1-6alkyl, etc; and k is 0 or an integer of 1 to 15); Y represents O, S, a bond, etc.; and Z represents an optionally substituted and saturated or unsaturated heterocycle containing 1 to 4 N, O or S atoms. Among all, compounds wherein Z is substituted chroman-2-yl, 2,3-dihydrobenzofuran-2-yl, etc. have an effect of inhibiting the formation of lipid peroxides too.
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Referential example 2
(2008/06/13)
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- p-CYMENE RUTHENIUM(II) COMPLEXES WITH 3-SUBSTITUTED PYRAZOLE LIGANDS
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The synthesis and characterisation of new mono- and dinuclear p-cymene-ruthenium(II) complexes (p-cymene = MeC6H4Pri-p) containing 3-substituted pyrazoles (LH) or pyrazolates (L) as ligands are reported .The new complexes belong to one of the following families (not all possible combinations): 6-p-cymene)RuCl2(LH)> (1-5),6-p-cymene)RuCl(LH)2>BF4 (6-11), 6-p-cymene)RuL(acac)> (acac = acetylacetonate) (12-15), 6-p-cymene)Ru(acac)(LH)>BF4 (16-19), 6-p-cymene)Ru(LH)3>2 (20-22), 6-p-cymene)RuL(LH)2>BF4 (23-25), 6-p-cymene)RuL2(LH)> (26-28), and the dinuclear 6-p-cymene)RuCl(μ-L)2M(CO)2> (M = Rh, Ir) (29-34).For the ruthenium-iridium complexes 6-p-cymene)RuCl(μ-ClPhpz)2Ir(CO)2> (33) and 6-p-cymene)RuCl(μ-MePhpz)2Ir(CO)2> (34) an equilibrium in solution is reached between two isomers that implies a reversible metal-metal bond formation accompanied by halide migration.
- Carmona, Daniel,Ferrer, Joaquina,Marzal, I. Miryam,Oro, Luis A.,Trofimenko, Swiatoslaw
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