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1H-Pyrrolo[2,3-b]pyridine, 4-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 4-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

    Cas No: 941685-08-1

  • USD $ 1.9-2.9 / Gram

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  • 941685-08-1 Structure
  • Basic information

    1. Product Name: 1H-Pyrrolo[2,3-b]pyridine, 4-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-
    2. Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 4-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-;4-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine;2-[(4-bromopyrrolo[2,3-b]pyridin-1-yl)methoxy]ethyl-trimethylsilane
    3. CAS NO:941685-08-1
    4. Molecular Formula: C13H19BrN2OSi
    5. Molecular Weight: 327.29226
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 941685-08-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 4-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 4-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-(941685-08-1)
    11. EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 4-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-(941685-08-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 941685-08-1(Hazardous Substances Data)

941685-08-1 Usage

Structure

Bromo-substituted pyrrolopyridine derivative

Contains

A trimethylsilyl group and an ethoxymethyl group

Usage

Building block or intermediate for the synthesis of various pharmaceuticals and bioactive molecules

Value

Unique structure and reactivity for the creation of diverse molecular structures with potential biological activities.

Check Digit Verification of cas no

The CAS Registry Mumber 941685-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,1,6,8 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 941685-08:
(8*9)+(7*4)+(6*1)+(5*6)+(4*8)+(3*5)+(2*0)+(1*8)=191
191 % 10 = 1
So 941685-08-1 is a valid CAS Registry Number.

941685-08-1Relevant articles and documents

PYRIDO-OXAZINE DERIVATIVES AS ALK5 INHIBITORS

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Page/Page column 76-77, (2022/01/24)

The present invention relates to a compound of general formula (I) inhibiting the growth factor receptor transforming β (TGF-β) type I (ALK5), methods for preparing such compounds, pharmaceutical compositions containing them and their therapeutic use. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the ALK5 signaling pathway in a mammal.

2, 4, 6-TRI-SUBSTITUTED PYRIMIDINE COMPOUND AS ATR KINASE INHIBITOR

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Paragraph 0155-0156, (2022/03/22)

Compounds of general formula (A) can be used for treating ATR kinase-mediated diseases, for example, hyperplastic diseases such as cancers. Also provided are a pharmaceutical composition of the compounds of general formula (A), a use of the pharmaceutical composition for treating the ATR kinase-mediated diseases and a preparation method for the pharmaceutical composition.

COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF

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Paragraph 0070-0071, (2021/10/30)

The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and alcoholic and non-alcoholic steatohepatitis (NASH).

Growth Factor Receptor antagonists. Preparation method and application thereof

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Paragraph 0233-0239, (2021/11/10)

The invention relates to a small molecule antagonist for transforming growth factor β receptors, a method for preparing the small molecule antagonist, and application of the small molecule antagonist in preparation of drugs. The small molecule antagonist for transforming the growth factor β receptor has the application of treating and/or preventing various diseases mediated by ALK5, and has great clinical application potential.

TYROSINE ANALOGUES DERIVATIVES AS RHO- KINASE INHIBITORS

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Page/Page column 56, (2019/04/09)

The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS

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Page/Page column 40; 42, (2019/07/13)

The invention relates to compounds of formula I inhibiting Rho Kinase that are tyrosine analogues derivatives, processes of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS

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Page/Page column 39; 40, (2020/01/08)

The invention relates to compounds of formula (I) inhibiting Rho Kinase that are azaindole derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof Particularly the compounds of the inventio

TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS

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Paragraph 0446-0447; 0462, (2018/08/20)

Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE INHIBITORS OF ATR KINASE

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Paragraph 0395; 0396, (2018/12/13)

The present invention relates to tetrahydropyrido[4,3-d]pyrimidine based compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

AZETIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

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Paragraph 0120; 0121; 0151; 0152; 0158; 0159; 0165; 0166, (2018/08/29)

The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, infl

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