- A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells
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Herein, a novel soluble mitochondria-targeted theranostic compound, HMX-1, was presented, which was selectively activated under hypoxia with excellent mitochondria-targeting ability at the cellular level, accompanied by a dramatic increase in the fluorescence intensity. Moreover, its anti-cancer efficiency was certified both in vitro and in vivo.
- Hu, Mingxing,Yang, Chao,Luo, Yi,Chen, Fan,Yang, Fangfang,Yang, Shuping,Chen, Hao,Cheng, Zhiqiang,Li, Kun,Xie, Yongmei
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p. 2413 - 2416
(2018/05/04)
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- HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS
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Hypoxia activated drug compounds having a structure of formula(I) are useful in the treatment of cancer and other hyperproliferative diseases.
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