Recyclable Cellulose-Derived Fe3O4@Pd NPs for Highly Selective C–S Formation by Heterogeneously C–H Sulfenylation of Indoles
Abstract: An efficient and convenient method was developed for the preparation of 3-sulfenylindoles via a cellulose-derived Fe3O4@Pd NPs catalyzed heterogeneously C–H sulfenylation of indoles. This approach provides an effective synthetic route to an important class of indoles derivatives and features high efficiency, easy operation, good practicality, and environmental friendliness. The recoverable catalyst was separated from the reaction mixture using an outside magnetic field and can be recycled five times without huge loss of catalytic performance. Graphic Abstract: An efficient method was developed for the preparation of 3-sulfenylindoles via cellulose-derived Fe3O4@Pd NPs catalyzed heterogeneously C–H sulfenylation of indoles.[Figure not available: see fulltext.].
Byproduct promoted regioselective sulfenylation of indoles with sulfinic acids
An unprecedented method to synthesise 3-sulfenylindoles is demonstrated via byproduct promoted sulfenylation of indoles with sulfinic acids in the absence of an external catalyst. The reaction selectively afforded structurally diverse indole thioethers in good to excellent yields in 1,2-dichloroethane at 80 °C. This journal is
Liu, Cong-Rong,Ding, Liang-Hui
supporting information
p. 2251 - 2254
(2015/03/04)
Iodine-catalyzed regioselective sulfenylation of indoles with sulfonyl hydrazides
New S in town: Sulfonyl hydrazides smoothly undergo sulfenylation with indoles in the presence of 10 mol % I2 to give structurally diverse indole thioethers in moderate to excellent yields with extremely high regioselectivity. This study paves the way for the use of sulfonyl hydrazides as unique sulfur electrophiles in chemical synthesis. Copyright
Yang, Fu-Lai,Tian, Shi-Kai
supporting information
p. 4929 - 4932
(2013/06/04)
Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles
The discovery of a series of 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles, dual acting norepinephrine reuptake inhibitors (NRIs) and 5-HT2A receptor antagonists, is described. The synthesis and structure-activity relationship (SAR) of this novel
Heffernan, Gavin D.,Coghlan, Richard D.,Manas, Eric S.,McDevitt, Robert E.,Li, Yanfang,Mahaney, Paige E.,Robichaud, Albert J.,Huselton, Christine,Alfinito, Peter,Bray, Jenifer A.,Cosmi, Scott A.,Johnston, Grace H.,Kenney, Thomas,Koury, Elizabeth,Winneker, Richard C.,Deecher, Darlene C.,Trybulski, Eugene J.
experimental part
p. 7802 - 7815
(2010/03/24)
SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS
The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical comp
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Page/Page column 84
(2008/06/13)
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